Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass

Lea Fayad; Cem Simsek; Dilhana Badurdeen; Christine Hill; Olaya I. Brewer Gutierrez; George Fayad; Margo Dunlap; Anthony N. Kalloo; Mouen A. Khashab; Marcia Canto; Vivek Kumbhari; Arvind J. Trindade; Petros C. Benias; Micheal Raad; Christopher C. Thompson

doi:10.1055/a-1086-3433

Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass

Lea Fayad, Cem Simsek, Dilhana Badurdeen, Christine Hill, Olaya I. Brewer Gutierrez, George Fayad, Margo Dunlap, Anthony N. Kalloo, Mouen A. Khashab, Marcia Canto, Vivek Kumbhari, Arvind J. Trindade, Petros C. Benias, Micheal Raad, Christopher C. Thompson

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background â Cryoballoon ablation could induce stricture formation to achieve outlet and pouch reduction in patients regaining weight after Roux-en-Y gastric bypass (RYGB). This pilot study aimed to assess technical feasibility and short-term efficacy. Methods â A retrospective chart review (JanuaryâŠ-âŠNovember 2018) at two academic centers identified patients with weight regain post-RYGB, treated with cryoablation if pouch >âŠ4âŠcm and/or outlet >âŠ15âŠmm. Patients were scheduled for surveillance endoscopies at 8 weeks. Results â22 patients presented 10.5 years (SD 4.42) post-RYGB with weight regain of 30.9âŠkg (SD 13.7). Technical success was 89.5âŠ% for outlet ablation and 93.0âŠ% for pouch ablation. From baseline to 8 weeks, the outlet was reduced from 24.1âŠmm (95âŠ% confidence interval [CI] 19.8 to 28.5) to 17.1âŠmm (95âŠ%CI 13.1 to 21.1; P âŠ<âŠ0.001), and pouch from 5âŠcm (95âŠ%CI 4.1 to 5.9) to 3.9âŠcm (95âŠ%CI 2.6 to 5.1; P âŠ<âŠ0.05). Total body weight loss at 8 weeks was 8.1âŠ% (SD 12.8âŠ%). Conclusion â Cryoablation appears technically feasible and effective for outlet and/or pouch reduction in the short term.

Original language	English (US)
Pages (from-to)	227-230
Number of pages	4
Journal	Endoscopy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1055/a-1086-3433
State	Published - Mar 1 2020

ASJC Scopus subject areas

Gastroenterology

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Fayad, L., Simsek, C., Badurdeen, D., Hill, C., Brewer Gutierrez, O. I., Fayad, G., Dunlap, M., Kalloo, A. N., Khashab, M. A., Canto, M., Kumbhari, V., Trindade, A. J., Benias, P. C., Raad, M., & Thompson, C. C. (2020). Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass. Endoscopy, 52(3), 227-230. https://doi.org/10.1055/a-1086-3433

Fayad, L, Simsek, C, Badurdeen, D, Hill, C, Brewer Gutierrez, OI, Fayad, G, Dunlap, M, Kalloo, AN , Khashab, MA , Canto, M, Kumbhari, V, Trindade, AJ, Benias, PC, Raad, M & Thompson, CC 2020, 'Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass', Endoscopy, vol. 52, no. 3, pp. 227-230. https://doi.org/10.1055/a-1086-3433

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title = "Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass",

abstract = "Background {\^a} Cryoballoon ablation could induce stricture formation to achieve outlet and pouch reduction in patients regaining weight after Roux-en-Y gastric bypass (RYGB). This pilot study aimed to assess technical feasibility and short-term efficacy. Methods {\^a} A retrospective chart review (January{\^a}{\v S}-{\^a}{\v S}November 2018) at two academic centers identified patients with weight regain post-RYGB, treated with cryoablation if pouch >{\^a}{\v S}4{\^a}{\v S}cm and/or outlet >{\^a}{\v S}15{\^a}{\v S}mm. Patients were scheduled for surveillance endoscopies at 8 weeks. Results {\^a}22 patients presented 10.5 years (SD 4.42) post-RYGB with weight regain of 30.9{\^a}{\v S}kg (SD 13.7). Technical success was 89.5{\^a}{\v S}% for outlet ablation and 93.0{\^a}{\v S}% for pouch ablation. From baseline to 8 weeks, the outlet was reduced from 24.1{\^a}{\v S}mm (95{\^a}{\v S}% confidence interval [CI] 19.8 to 28.5) to 17.1{\^a}{\v S}mm (95{\^a}{\v S}%CI 13.1 to 21.1; P {\^a}{\v S}<{\^a}{\v S}0.001), and pouch from 5{\^a}{\v S}cm (95{\^a}{\v S}%CI 4.1 to 5.9) to 3.9{\^a}{\v S}cm (95{\^a}{\v S}%CI 2.6 to 5.1; P {\^a}{\v S}<{\^a}{\v S}0.05). Total body weight loss at 8 weeks was 8.1{\^a}{\v S}% (SD 12.8{\^a}{\v S}%). Conclusion {\^a} Cryoablation appears technically feasible and effective for outlet and/or pouch reduction in the short term.",

author = "Lea Fayad and Cem Simsek and Dilhana Badurdeen and Christine Hill and {Brewer Gutierrez}, {Olaya I.} and George Fayad and Margo Dunlap and Kalloo, {Anthony N.} and Khashab, {Mouen A.} and Marcia Canto and Vivek Kumbhari and Trindade, {Arvind J.} and Benias, {Petros C.} and Micheal Raad and Thompson, {Christopher C.}",

year = "2020",

month = mar,

day = "1",

doi = "10.1055/a-1086-3433",

language = "English (US)",

volume = "52",

pages = "227--230",

journal = "Endoscopy",

issn = "0013-726X",

publisher = "Georg Thieme Verlag",

number = "3",

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TY - JOUR

T1 - Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass

AU - Fayad, Lea

AU - Simsek, Cem

AU - Badurdeen, Dilhana

AU - Hill, Christine

AU - Brewer Gutierrez, Olaya I.

AU - Fayad, George

AU - Dunlap, Margo

AU - Kalloo, Anthony N.

AU - Khashab, Mouen A.

AU - Canto, Marcia

AU - Kumbhari, Vivek

AU - Trindade, Arvind J.

AU - Benias, Petros C.

AU - Raad, Micheal

AU - Thompson, Christopher C.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background â Cryoballoon ablation could induce stricture formation to achieve outlet and pouch reduction in patients regaining weight after Roux-en-Y gastric bypass (RYGB). This pilot study aimed to assess technical feasibility and short-term efficacy. Methods â A retrospective chart review (JanuaryâŠ-âŠNovember 2018) at two academic centers identified patients with weight regain post-RYGB, treated with cryoablation if pouch >âŠ4âŠcm and/or outlet >âŠ15âŠmm. Patients were scheduled for surveillance endoscopies at 8 weeks. Results â22 patients presented 10.5 years (SD 4.42) post-RYGB with weight regain of 30.9âŠkg (SD 13.7). Technical success was 89.5âŠ% for outlet ablation and 93.0âŠ% for pouch ablation. From baseline to 8 weeks, the outlet was reduced from 24.1âŠmm (95âŠ% confidence interval [CI] 19.8 to 28.5) to 17.1âŠmm (95âŠ%CI 13.1 to 21.1; P âŠ<âŠ0.001), and pouch from 5âŠcm (95âŠ%CI 4.1 to 5.9) to 3.9âŠcm (95âŠ%CI 2.6 to 5.1; P âŠ<âŠ0.05). Total body weight loss at 8 weeks was 8.1âŠ% (SD 12.8âŠ%). Conclusion â Cryoablation appears technically feasible and effective for outlet and/or pouch reduction in the short term.

AB - Background â Cryoballoon ablation could induce stricture formation to achieve outlet and pouch reduction in patients regaining weight after Roux-en-Y gastric bypass (RYGB). This pilot study aimed to assess technical feasibility and short-term efficacy. Methods â A retrospective chart review (JanuaryâŠ-âŠNovember 2018) at two academic centers identified patients with weight regain post-RYGB, treated with cryoablation if pouch >âŠ4âŠcm and/or outlet >âŠ15âŠmm. Patients were scheduled for surveillance endoscopies at 8 weeks. Results â22 patients presented 10.5 years (SD 4.42) post-RYGB with weight regain of 30.9âŠkg (SD 13.7). Technical success was 89.5âŠ% for outlet ablation and 93.0âŠ% for pouch ablation. From baseline to 8 weeks, the outlet was reduced from 24.1âŠmm (95âŠ% confidence interval [CI] 19.8 to 28.5) to 17.1âŠmm (95âŠ%CI 13.1 to 21.1; P âŠ<âŠ0.001), and pouch from 5âŠcm (95âŠ%CI 4.1 to 5.9) to 3.9âŠcm (95âŠ%CI 2.6 to 5.1; P âŠ<âŠ0.05). Total body weight loss at 8 weeks was 8.1âŠ% (SD 12.8âŠ%). Conclusion â Cryoablation appears technically feasible and effective for outlet and/or pouch reduction in the short term.

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DO - 10.1055/a-1086-3433

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C2 - 31975351

AN - SCOPUS:85080957550

SN - 0013-726X

VL - 52

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EP - 230

JO - Endoscopy

JF - Endoscopy

IS - 3

ER -

Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass

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