Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass

Lea Fayad, Cem Simsek, Dilhana Badurdeen, Christine Hill, Olaya I. Brewer Gutierrez, George Fayad, Margo Dunlap, Anthony N. Kalloo, Mouen A. Khashab, Marcia Canto, Vivek Kumbhari, Arvind J. Trindade, Petros C. Benias, Micheal Raad, Christopher C. Thompson

Research output: Contribution to journalArticle

Abstract

Background â Cryoballoon ablation could induce stricture formation to achieve outlet and pouch reduction in patients regaining weight after Roux-en-Y gastric bypass (RYGB). This pilot study aimed to assess technical feasibility and short-term efficacy. Methods â A retrospective chart review (JanuaryâŠ-âŠNovember 2018) at two academic centers identified patients with weight regain post-RYGB, treated with cryoablation if pouch >âŠ4âŠcm and/or outlet >âŠ15âŠmm. Patients were scheduled for surveillance endoscopies at 8 weeks. Results â22 patients presented 10.5 years (SD 4.42) post-RYGB with weight regain of 30.9âŠkg (SD 13.7). Technical success was 89.5âŠ% for outlet ablation and 93.0âŠ% for pouch ablation. From baseline to 8 weeks, the outlet was reduced from 24.1âŠmm (95âŠ% confidence interval [CI] 19.8 to 28.5) to 17.1âŠmm (95âŠ%CI 13.1 to 21.1; P âŠ<âŠ0.001), and pouch from 5âŠcm (95âŠ%CI 4.1 to 5.9) to 3.9âŠcm (95âŠ%CI 2.6 to 5.1; P âŠ<âŠ0.05). Total body weight loss at 8 weeks was 8.1âŠ% (SD 12.8âŠ%). Conclusion â Cryoablation appears technically feasible and effective for outlet and/or pouch reduction in the short term.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalEndoscopy
Volume52
Issue number3
DOIs
StatePublished - Mar 1 2020

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ASJC Scopus subject areas

  • Gastroenterology

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Fayad, L., Simsek, C., Badurdeen, D., Hill, C., Brewer Gutierrez, O. I., Fayad, G., Dunlap, M., Kalloo, A. N., Khashab, M. A., Canto, M., Kumbhari, V., Trindade, A. J., Benias, P. C., Raad, M., & Thompson, C. C. (2020). Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass. Endoscopy, 52(3), 227-230. https://doi.org/10.1055/a-1086-3433