Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Genevera I. Allen, Nicola Amoroso, Catalina Anghel, Venkat Balagurusamy, Christopher J. Bare, Derek Beaton, Roberto Bellotti, David A. Bennett, Kevin L. Boehme, Paul C. Boutros, Laura Caberlotto, Cristian Caloian, Frederick Campbell, Elias Chaibub Neto, Yu Chuan Chang, Beibei Chen, Chien Yu Chen, Ting Ying Chien, Tim Clark, Sudeshna Das & 81 others Christos Davatzikos, Jieyao Deng, Donna Dillenberger, Richard J B Dobson, Qilin Dong, Jimit Doshi, Denise Duma, Rosangela Errico, Guray Erus, Evan Everett, David W. Fardo, Stephen H. Friend, Holger Fröhlich, Jessica Gan, Peter St George-Hyslop, Satrajit S. Ghosh, Enrico Glaab, Robert C. Green, Yuanfang Guan, Ming Yi Hong, Chao Huang, Jinseub Hwang, Joseph Ibrahim, Paolo Inglese, Anandhi Iyappan, Qijia Jiang, Yuriko Katsumata, John S K Kauwe, Arno Klein, Dehan Kong, Roland Krause, Emilie Lalonde, Mario Lauria, Eunjee Lee, Xihui Lin, Zhandong Liu, Julie Livingstone, Benjamin A. Logsdon, Simon Lovestone, Tsung Wei Ma, Ashutosh Malhotra, Lara M. Mangravite, Taylor J. Maxwell, Emily Merrill, John Nagorski, Aishwarya Namasivayam, Manjari Narayan, Mufassra Naz, Stephen J. Newhouse, Thea C. Norman, Ramil N. Nurtdinov, Yen Jen Oyang, Yudi Pawitan, Shengwen Peng, Mette A. Peters, Stephen R. Piccolo, Paurush Praveen, Corrado Priami, Veronica Y. Sabelnykova, Philipp Senger, Xia Shen, Andrew Simmons, Aristeidis Sotiras, Gustavo Stolovitzky, Sabina Tangaro, Andrea Tateo, Yi An Tung, Nicholas J. Tustison, Erdem Varol, George Vradenburg, Michael W. Weiner, Guanghua Xiao, Lei Xie, Yang Xie, Jia Xu, Hojin Yang, Xiaowei Zhan, Yunyun Zhou, Fan Zhu, Hongtu Zhu, Shanfeng Zhu

Research output: Contribution to journalArticle

Abstract

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-The-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.

Original languageEnglish (US)
Pages (from-to)645-653
Number of pages9
JournalAlzheimer's and Dementia
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Alzheimer Disease
Benchmarking
Meta-Analysis
Early Diagnosis
Biomarkers
Cognitive Dysfunction
Therapeutics

Keywords

  • Azheimer's disease
  • Big data
  • Bioinformatics
  • Biomarkers
  • Cognitive decline
  • Crowdsource
  • Genetics
  • Imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Allen, G. I., Amoroso, N., Anghel, C., Balagurusamy, V., Bare, C. J., Beaton, D., ... Zhu, S. (2016). Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimer's and Dementia, 12(6), 645-653. https://doi.org/10.1016/j.jalz.2016.02.006

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. / Allen, Genevera I.; Amoroso, Nicola; Anghel, Catalina; Balagurusamy, Venkat; Bare, Christopher J.; Beaton, Derek; Bellotti, Roberto; Bennett, David A.; Boehme, Kevin L.; Boutros, Paul C.; Caberlotto, Laura; Caloian, Cristian; Campbell, Frederick; Chaibub Neto, Elias; Chang, Yu Chuan; Chen, Beibei; Chen, Chien Yu; Chien, Ting Ying; Clark, Tim; Das, Sudeshna; Davatzikos, Christos; Deng, Jieyao; Dillenberger, Donna; Dobson, Richard J B; Dong, Qilin; Doshi, Jimit; Duma, Denise; Errico, Rosangela; Erus, Guray; Everett, Evan; Fardo, David W.; Friend, Stephen H.; Fröhlich, Holger; Gan, Jessica; St George-Hyslop, Peter; Ghosh, Satrajit S.; Glaab, Enrico; Green, Robert C.; Guan, Yuanfang; Hong, Ming Yi; Huang, Chao; Hwang, Jinseub; Ibrahim, Joseph; Inglese, Paolo; Iyappan, Anandhi; Jiang, Qijia; Katsumata, Yuriko; Kauwe, John S K; Klein, Arno; Kong, Dehan; Krause, Roland; Lalonde, Emilie; Lauria, Mario; Lee, Eunjee; Lin, Xihui; Liu, Zhandong; Livingstone, Julie; Logsdon, Benjamin A.; Lovestone, Simon; Ma, Tsung Wei; Malhotra, Ashutosh; Mangravite, Lara M.; Maxwell, Taylor J.; Merrill, Emily; Nagorski, John; Namasivayam, Aishwarya; Narayan, Manjari; Naz, Mufassra; Newhouse, Stephen J.; Norman, Thea C.; Nurtdinov, Ramil N.; Oyang, Yen Jen; Pawitan, Yudi; Peng, Shengwen; Peters, Mette A.; Piccolo, Stephen R.; Praveen, Paurush; Priami, Corrado; Sabelnykova, Veronica Y.; Senger, Philipp; Shen, Xia; Simmons, Andrew; Sotiras, Aristeidis; Stolovitzky, Gustavo; Tangaro, Sabina; Tateo, Andrea; Tung, Yi An; Tustison, Nicholas J.; Varol, Erdem; Vradenburg, George; Weiner, Michael W.; Xiao, Guanghua; Xie, Lei; Xie, Yang; Xu, Jia; Yang, Hojin; Zhan, Xiaowei; Zhou, Yunyun; Zhu, Fan; Zhu, Hongtu; Zhu, Shanfeng.

In: Alzheimer's and Dementia, Vol. 12, No. 6, 01.06.2016, p. 645-653.

Research output: Contribution to journalArticle

Allen, GI, Amoroso, N, Anghel, C, Balagurusamy, V, Bare, CJ, Beaton, D, Bellotti, R, Bennett, DA, Boehme, KL, Boutros, PC, Caberlotto, L, Caloian, C, Campbell, F, Chaibub Neto, E, Chang, YC, Chen, B, Chen, CY, Chien, TY, Clark, T, Das, S, Davatzikos, C, Deng, J, Dillenberger, D, Dobson, RJB, Dong, Q, Doshi, J, Duma, D, Errico, R, Erus, G, Everett, E, Fardo, DW, Friend, SH, Fröhlich, H, Gan, J, St George-Hyslop, P, Ghosh, SS, Glaab, E, Green, RC, Guan, Y, Hong, MY, Huang, C, Hwang, J, Ibrahim, J, Inglese, P, Iyappan, A, Jiang, Q, Katsumata, Y, Kauwe, JSK, Klein, A, Kong, D, Krause, R, Lalonde, E, Lauria, M, Lee, E, Lin, X, Liu, Z, Livingstone, J, Logsdon, BA, Lovestone, S, Ma, TW, Malhotra, A, Mangravite, LM, Maxwell, TJ, Merrill, E, Nagorski, J, Namasivayam, A, Narayan, M, Naz, M, Newhouse, SJ, Norman, TC, Nurtdinov, RN, Oyang, YJ, Pawitan, Y, Peng, S, Peters, MA, Piccolo, SR, Praveen, P, Priami, C, Sabelnykova, VY, Senger, P, Shen, X, Simmons, A, Sotiras, A, Stolovitzky, G, Tangaro, S, Tateo, A, Tung, YA, Tustison, NJ, Varol, E, Vradenburg, G, Weiner, MW, Xiao, G, Xie, L, Xie, Y, Xu, J, Yang, H, Zhan, X, Zhou, Y, Zhu, F, Zhu, H & Zhu, S 2016, 'Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease', Alzheimer's and Dementia, vol. 12, no. 6, pp. 645-653. https://doi.org/10.1016/j.jalz.2016.02.006
Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D et al. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimer's and Dementia. 2016 Jun 1;12(6):645-653. https://doi.org/10.1016/j.jalz.2016.02.006
Allen, Genevera I. ; Amoroso, Nicola ; Anghel, Catalina ; Balagurusamy, Venkat ; Bare, Christopher J. ; Beaton, Derek ; Bellotti, Roberto ; Bennett, David A. ; Boehme, Kevin L. ; Boutros, Paul C. ; Caberlotto, Laura ; Caloian, Cristian ; Campbell, Frederick ; Chaibub Neto, Elias ; Chang, Yu Chuan ; Chen, Beibei ; Chen, Chien Yu ; Chien, Ting Ying ; Clark, Tim ; Das, Sudeshna ; Davatzikos, Christos ; Deng, Jieyao ; Dillenberger, Donna ; Dobson, Richard J B ; Dong, Qilin ; Doshi, Jimit ; Duma, Denise ; Errico, Rosangela ; Erus, Guray ; Everett, Evan ; Fardo, David W. ; Friend, Stephen H. ; Fröhlich, Holger ; Gan, Jessica ; St George-Hyslop, Peter ; Ghosh, Satrajit S. ; Glaab, Enrico ; Green, Robert C. ; Guan, Yuanfang ; Hong, Ming Yi ; Huang, Chao ; Hwang, Jinseub ; Ibrahim, Joseph ; Inglese, Paolo ; Iyappan, Anandhi ; Jiang, Qijia ; Katsumata, Yuriko ; Kauwe, John S K ; Klein, Arno ; Kong, Dehan ; Krause, Roland ; Lalonde, Emilie ; Lauria, Mario ; Lee, Eunjee ; Lin, Xihui ; Liu, Zhandong ; Livingstone, Julie ; Logsdon, Benjamin A. ; Lovestone, Simon ; Ma, Tsung Wei ; Malhotra, Ashutosh ; Mangravite, Lara M. ; Maxwell, Taylor J. ; Merrill, Emily ; Nagorski, John ; Namasivayam, Aishwarya ; Narayan, Manjari ; Naz, Mufassra ; Newhouse, Stephen J. ; Norman, Thea C. ; Nurtdinov, Ramil N. ; Oyang, Yen Jen ; Pawitan, Yudi ; Peng, Shengwen ; Peters, Mette A. ; Piccolo, Stephen R. ; Praveen, Paurush ; Priami, Corrado ; Sabelnykova, Veronica Y. ; Senger, Philipp ; Shen, Xia ; Simmons, Andrew ; Sotiras, Aristeidis ; Stolovitzky, Gustavo ; Tangaro, Sabina ; Tateo, Andrea ; Tung, Yi An ; Tustison, Nicholas J. ; Varol, Erdem ; Vradenburg, George ; Weiner, Michael W. ; Xiao, Guanghua ; Xie, Lei ; Xie, Yang ; Xu, Jia ; Yang, Hojin ; Zhan, Xiaowei ; Zhou, Yunyun ; Zhu, Fan ; Zhu, Hongtu ; Zhu, Shanfeng. / Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. In: Alzheimer's and Dementia. 2016 ; Vol. 12, No. 6. pp. 645-653.
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T1 - Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

AU - Allen, Genevera I.

AU - Amoroso, Nicola

AU - Anghel, Catalina

AU - Balagurusamy, Venkat

AU - Bare, Christopher J.

AU - Beaton, Derek

AU - Bellotti, Roberto

AU - Bennett, David A.

AU - Boehme, Kevin L.

AU - Boutros, Paul C.

AU - Caberlotto, Laura

AU - Caloian, Cristian

AU - Campbell, Frederick

AU - Chaibub Neto, Elias

AU - Chang, Yu Chuan

AU - Chen, Beibei

AU - Chen, Chien Yu

AU - Chien, Ting Ying

AU - Clark, Tim

AU - Das, Sudeshna

AU - Davatzikos, Christos

AU - Deng, Jieyao

AU - Dillenberger, Donna

AU - Dobson, Richard J B

AU - Dong, Qilin

AU - Doshi, Jimit

AU - Duma, Denise

AU - Errico, Rosangela

AU - Erus, Guray

AU - Everett, Evan

AU - Fardo, David W.

AU - Friend, Stephen H.

AU - Fröhlich, Holger

AU - Gan, Jessica

AU - St George-Hyslop, Peter

AU - Ghosh, Satrajit S.

AU - Glaab, Enrico

AU - Green, Robert C.

AU - Guan, Yuanfang

AU - Hong, Ming Yi

AU - Huang, Chao

AU - Hwang, Jinseub

AU - Ibrahim, Joseph

AU - Inglese, Paolo

AU - Iyappan, Anandhi

AU - Jiang, Qijia

AU - Katsumata, Yuriko

AU - Kauwe, John S K

AU - Klein, Arno

AU - Kong, Dehan

AU - Krause, Roland

AU - Lalonde, Emilie

AU - Lauria, Mario

AU - Lee, Eunjee

AU - Lin, Xihui

AU - Liu, Zhandong

AU - Livingstone, Julie

AU - Logsdon, Benjamin A.

AU - Lovestone, Simon

AU - Ma, Tsung Wei

AU - Malhotra, Ashutosh

AU - Mangravite, Lara M.

AU - Maxwell, Taylor J.

AU - Merrill, Emily

AU - Nagorski, John

AU - Namasivayam, Aishwarya

AU - Narayan, Manjari

AU - Naz, Mufassra

AU - Newhouse, Stephen J.

AU - Norman, Thea C.

AU - Nurtdinov, Ramil N.

AU - Oyang, Yen Jen

AU - Pawitan, Yudi

AU - Peng, Shengwen

AU - Peters, Mette A.

AU - Piccolo, Stephen R.

AU - Praveen, Paurush

AU - Priami, Corrado

AU - Sabelnykova, Veronica Y.

AU - Senger, Philipp

AU - Shen, Xia

AU - Simmons, Andrew

AU - Sotiras, Aristeidis

AU - Stolovitzky, Gustavo

AU - Tangaro, Sabina

AU - Tateo, Andrea

AU - Tung, Yi An

AU - Tustison, Nicholas J.

AU - Varol, Erdem

AU - Vradenburg, George

AU - Weiner, Michael W.

AU - Xiao, Guanghua

AU - Xie, Lei

AU - Xie, Yang

AU - Xu, Jia

AU - Yang, Hojin

AU - Zhan, Xiaowei

AU - Zhou, Yunyun

AU - Zhu, Fan

AU - Zhu, Hongtu

AU - Zhu, Shanfeng

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KW - Big data

KW - Bioinformatics

KW - Biomarkers

KW - Cognitive decline

KW - Crowdsource

KW - Genetics

KW - Imaging

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