Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment

Hua Yu, Marcin Kortylewski, Drew Pardoll

Research output: Contribution to journalReview article

Abstract

Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour immune response, but also interact intimately with the transformed cells to promote oncogenesis actively. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activated both in tumour cells and in immune cells in the tumour microenvironment. Constitutively activated STAT3 inhibits the expression of mediators necessary for immune activation against tumour cells. Furthermore, STAT3 activity promotes the production of immunosuppressive factors that activate STAT3 in diverse immune-cell subsets, altering gene-expression programmes and, thereby, restraining anti-tumour immune responses. As such, STAT3 propagates several levels of crosstalk between tumour cells and their immunological microenvironment, leading to tumour-induced immunosuppression. Consequently, STAT3 has emerged as a promising target for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalNature Reviews Immunology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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