Cross-vendor harmonization of T2-relaxation-under-spin-tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Dengrong Jiang, Peiying Liu, Yang Li, Deng Mao, Cuimei Xu, Hanzhang Lu

Research output: Contribution to journalArticle

Abstract

Purpose: Cerebral venous oxygenation (Yv) is an important physiological parameter and has potential clinical application in many brain diseases. T2-relaxation-under-spin-tagging (TRUST) is a commonly used MRI method to measure Yv. Harmonization of this technique across MRI vendors is important for dissemination and multicenter studies of brain oxygenation and metabolism as a disease biomarker. Methods: TRUST pulse sequence components and imaging parameters were carefully matched between two major MRI vendors, Philips and Siemens. Each subject (N = 10) was scanned on both scanners within a 2.5-h period. On each scanner, the subject was scanned in two sessions to assess intersession reproducibility. A hyperoxia challenge was also included in both sessions and on both scanners to evaluate the sensitivity of the technique to Yv changes. Measured Yv values, confidence interval of Yv estimates (εYv), as well as intrasession and intersession coefficient of variation (CoV) of Yv, were compared between the two scanners. Results: Yv measured on the two vendors were highly compatible and strongly correlated (R2 = 0.957). Yv changes associated with hyperoxia challenge were significant on both scanners (P < 0.001) and were also correlated across scanners (P = 0.007). Intrasession and intersession CoV of measured Yv were less than 3% and showed no difference between scanners. εYv were less than 1% on both scanners and showed no difference between scanners when echo times were matched on the two scanners. Conclusion: This work suggests that harmonized TRUST MRI can yield highly compatible Yv measurements across different vendors. Magn Reson Med 80:1125–1131, 2018.

Original languageEnglish (US)
Pages (from-to)1125-1131
Number of pages7
JournalMagnetic Resonance in Medicine
Volume80
Issue number3
DOIs
StatePublished - Sep 1 2018

Fingerprint

Hyperoxia
Brain Diseases
Multicenter Studies
Biomarkers
Confidence Intervals
Brain

Keywords

  • reproducibility
  • TRUST
  • variation
  • vendor
  • venous oxygenation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Cross-vendor harmonization of T2-relaxation-under-spin-tagging (TRUST) MRI for the assessment of cerebral venous oxygenation. / Jiang, Dengrong; Liu, Peiying; Li, Yang; Mao, Deng; Xu, Cuimei; Lu, Hanzhang.

In: Magnetic Resonance in Medicine, Vol. 80, No. 3, 01.09.2018, p. 1125-1131.

Research output: Contribution to journalArticle

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abstract = "Purpose: Cerebral venous oxygenation (Yv) is an important physiological parameter and has potential clinical application in many brain diseases. T2-relaxation-under-spin-tagging (TRUST) is a commonly used MRI method to measure Yv. Harmonization of this technique across MRI vendors is important for dissemination and multicenter studies of brain oxygenation and metabolism as a disease biomarker. Methods: TRUST pulse sequence components and imaging parameters were carefully matched between two major MRI vendors, Philips and Siemens. Each subject (N = 10) was scanned on both scanners within a 2.5-h period. On each scanner, the subject was scanned in two sessions to assess intersession reproducibility. A hyperoxia challenge was also included in both sessions and on both scanners to evaluate the sensitivity of the technique to Yv changes. Measured Yv values, confidence interval of Yv estimates (εYv), as well as intrasession and intersession coefficient of variation (CoV) of Yv, were compared between the two scanners. Results: Yv measured on the two vendors were highly compatible and strongly correlated (R2 = 0.957). Yv changes associated with hyperoxia challenge were significant on both scanners (P < 0.001) and were also correlated across scanners (P = 0.007). Intrasession and intersession CoV of measured Yv were less than 3{\%} and showed no difference between scanners. εYv were less than 1{\%} on both scanners and showed no difference between scanners when echo times were matched on the two scanners. Conclusion: This work suggests that harmonized TRUST MRI can yield highly compatible Yv measurements across different vendors. Magn Reson Med 80:1125–1131, 2018.",
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