Cross-talk between two essential nutrient-sensitive enzymes O-GlcNAc Transferase (OGT) and Amp-Activated Protein Kinase (AMPK)

John W. Bullen, Jeremy L. Balsbaugh, Dipanjan Chanda, Jeffrey Shabanowitz, Donald F. Hunt, Dietbert Neumann, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

Background: OGT and AMPK collectively target hundreds of intracellular signaling processes, but no study has addressed whether they regulate each other. Results: AMPK activity mediates the substrate selectivity of OGT, and O-GlcNAcylation modulates the activity of AMPK. Conclusion: There is significant cross-talk between the O-GlcNAc and AMPK systems. Significance: OGT and AMPK may synergistically regulate numerous nutrient-sensitive processes essential for life.

Original languageEnglish (US)
Pages (from-to)10592-10606
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
StatePublished - Apr 11 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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    Bullen, J. W., Balsbaugh, J. L., Chanda, D., Shabanowitz, J., Hunt, D. F., Neumann, D., & Hart, G. W. (2014). Cross-talk between two essential nutrient-sensitive enzymes O-GlcNAc Transferase (OGT) and Amp-Activated Protein Kinase (AMPK). Journal of Biological Chemistry, 289(15), 10592-10606. https://doi.org/10.1074/jbc.M113.523068