@article{cb55e191d08a4b888f934d4c76657a0f,
title = "Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy",
abstract = "To identify regulatory drivers of prostate cancer malignancy, we have assembled genome-wide regulatory networks (interactomes) for human and mouse prostate cancer from expression profiles of human tumors and of genetically engineered mouse models, respectively. Cross-species computational analysis of these interactomes has identified FOXM1 and CENPF as synergistic master regulators of prostate cancer malignancy. Experimental validation shows that FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy. Furthermore, co-expression of FOXM1 and CENPF is a robust prognostic indicator of poor survival and metastasis. Thus, genome-wide cross-species interrogation of regulatory networks represents a valuable strategy to identify causal mechanisms of human cancer.",
author = "Alvaro Aytes and Antonina Mitrofanova and Celine Lefebvre and Alvarez, {Mariano J.} and Mireia Castillo-Martin and Tian Zheng and Eastham, {James A.} and Anuradha Gopalan and Pienta, {Kenneth J.} and Shen, {Michael M.} and Andrea Califano and Cory Abate-Shen",
note = "Funding Information: This work was supported by grants CA084294 (to C.A.S., M.M.S., and A.C.), U54 CA121852 (to A.C., C.A.S., and M.M.S.), CA154293 (to M.M.S. and C.A.S.), DK076602 (to M.M.S.), Cancer Target Discovery and Development Centers NCI U01 CA168426 (to A.C.), the Michigan Center for Translational Pathology, SPORE grant P50 CA69568 (to K.J.P.), and an award from the V-Foundation for Cancer Research (to C.A.S.). A.A. was a recipient of a Marie Curie International Outgoing Fellowship (PIOF-GA-2009-253290), cosponsored with the Catalan Institute of Oncology-Bellvitge Institute for Biomedical Research, Barcelona, Spain. A.M. is a recipient of a Prostate Cancer Foundation Young Investigator Award. C.A.S. is an American Cancer Society Research Professor supported in part by a generous gift from the F.M. Kirby Foundation. ",
year = "2014",
month = may,
day = "12",
doi = "10.1016/j.ccr.2014.03.017",
language = "English (US)",
volume = "25",
pages = "638--651",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}