Cross-sectional assessment of pain and physical function in skeletal dysplasia patients

Research output: Contribution to journalArticle

Abstract

Short stature skeletal dysplasia (SD) patients have orthopedic and neurologic complications causing significant pain and physical disability. We conducted a large cross-sectional online survey in 361 people with short stature SD (>10years) to describe pain prevalence, characteristics, and the relationship between pain and function. Chronic pain prevalence per Brief Pain Inventory (BPI) was 70.3%. Women reported more pain than men (73% vs 63% p=0.04). Pain Severity Score (average of current, worst, least and average pain) averaged 3.3±2, while the Pain Interference Score (with daily activities) averaged 3.4±2.7 on a 10-point scale. Per Bleck scale, 20.5% had little or no functional capacity. Increasing age and decreased ambulation independently predicted chronic pain. Chronic pain is prevalent in short stature SD patients and associated with poor physical function. Further study is required to clarify the temporal relationship among pain, function and treatments.

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalClinical Genetics
Volume84
Issue number3
DOIs
StatePublished - Sep 2013

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Pain Measurement
Pain
Chronic Pain
Nervous System
Walking
Orthopedics
Cross-Sectional Studies
Equipment and Supplies

Keywords

  • Achondroplasia
  • Mobility
  • Pain
  • Skeletal dysplasia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

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title = "Cross-sectional assessment of pain and physical function in skeletal dysplasia patients",
abstract = "Short stature skeletal dysplasia (SD) patients have orthopedic and neurologic complications causing significant pain and physical disability. We conducted a large cross-sectional online survey in 361 people with short stature SD (>10years) to describe pain prevalence, characteristics, and the relationship between pain and function. Chronic pain prevalence per Brief Pain Inventory (BPI) was 70.3{\%}. Women reported more pain than men (73{\%} vs 63{\%} p=0.04). Pain Severity Score (average of current, worst, least and average pain) averaged 3.3±2, while the Pain Interference Score (with daily activities) averaged 3.4±2.7 on a 10-point scale. Per Bleck scale, 20.5{\%} had little or no functional capacity. Increasing age and decreased ambulation independently predicted chronic pain. Chronic pain is prevalent in short stature SD patients and associated with poor physical function. Further study is required to clarify the temporal relationship among pain, function and treatments.",
keywords = "Achondroplasia, Mobility, Pain, Skeletal dysplasia",
author = "Y. Alade and Tunkel, {David E} and Schulze, {Kerry J} and John McGready and George Jallo and Michael Ain and T. Yost and {Hoover Fong}, {Julie E}",
year = "2013",
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volume = "84",
pages = "237--243",
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T1 - Cross-sectional assessment of pain and physical function in skeletal dysplasia patients

AU - Alade, Y.

AU - Tunkel, David E

AU - Schulze, Kerry J

AU - McGready, John

AU - Jallo, George

AU - Ain, Michael

AU - Yost, T.

AU - Hoover Fong, Julie E

PY - 2013/9

Y1 - 2013/9

N2 - Short stature skeletal dysplasia (SD) patients have orthopedic and neurologic complications causing significant pain and physical disability. We conducted a large cross-sectional online survey in 361 people with short stature SD (>10years) to describe pain prevalence, characteristics, and the relationship between pain and function. Chronic pain prevalence per Brief Pain Inventory (BPI) was 70.3%. Women reported more pain than men (73% vs 63% p=0.04). Pain Severity Score (average of current, worst, least and average pain) averaged 3.3±2, while the Pain Interference Score (with daily activities) averaged 3.4±2.7 on a 10-point scale. Per Bleck scale, 20.5% had little or no functional capacity. Increasing age and decreased ambulation independently predicted chronic pain. Chronic pain is prevalent in short stature SD patients and associated with poor physical function. Further study is required to clarify the temporal relationship among pain, function and treatments.

AB - Short stature skeletal dysplasia (SD) patients have orthopedic and neurologic complications causing significant pain and physical disability. We conducted a large cross-sectional online survey in 361 people with short stature SD (>10years) to describe pain prevalence, characteristics, and the relationship between pain and function. Chronic pain prevalence per Brief Pain Inventory (BPI) was 70.3%. Women reported more pain than men (73% vs 63% p=0.04). Pain Severity Score (average of current, worst, least and average pain) averaged 3.3±2, while the Pain Interference Score (with daily activities) averaged 3.4±2.7 on a 10-point scale. Per Bleck scale, 20.5% had little or no functional capacity. Increasing age and decreased ambulation independently predicted chronic pain. Chronic pain is prevalent in short stature SD patients and associated with poor physical function. Further study is required to clarify the temporal relationship among pain, function and treatments.

KW - Achondroplasia

KW - Mobility

KW - Pain

KW - Skeletal dysplasia

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U2 - 10.1111/cge.12045

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