TY - JOUR
T1 - Cross-reactivity between cell-surface antigens of different murine carcinogen-induced tumors, demonstrated by a modified isotopic antiglobulin test
AU - Burdick, James F.
AU - Wells, Samuel A.
PY - 1973/10
Y1 - 1973/10
N2 - The isotopic antiglobulin test modified for use with tissue culture cellsgrown as adherent monolayers resulted in aquick, sensitive microassay. Serum, prepared from blood of mice hyperimmunizedwith a syngeneic C57BL/6N tumor inducedby 3-methylcholanthrene (MCA) in vitro, cross-reacted with 3 of 7 different MCA-induced tumors. After absorption of serum, the activity was blocked by all MCA-inducedtumor lines and a normal fibroblast line, butnot by normal spleen cells. There was a weakcross-reactivity with murine Moloney andGross virus-induced tumors. A similar weakreactivity with C57BL/6N multiparous exbreeder serum indicated a possible relationship to fetal antigen.
AB - The isotopic antiglobulin test modified for use with tissue culture cellsgrown as adherent monolayers resulted in aquick, sensitive microassay. Serum, prepared from blood of mice hyperimmunizedwith a syngeneic C57BL/6N tumor inducedby 3-methylcholanthrene (MCA) in vitro, cross-reacted with 3 of 7 different MCA-induced tumors. After absorption of serum, the activity was blocked by all MCA-inducedtumor lines and a normal fibroblast line, butnot by normal spleen cells. There was a weakcross-reactivity with murine Moloney andGross virus-induced tumors. A similar weakreactivity with C57BL/6N multiparous exbreeder serum indicated a possible relationship to fetal antigen.
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U2 - 10.1093/jnci/51.4.1149
DO - 10.1093/jnci/51.4.1149
M3 - Article
C2 - 4745853
AN - SCOPUS:0015885715
SN - 0027-8874
VL - 51
SP - 1149
EP - 1156
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 4
ER -