Cross-reactivity between cell-surface antigens of different murine carcinogen-induced tumors, demonstrated by a modified isotopic antiglobulin test

James F. Burdick, Samuel A. Wells

Research output: Contribution to journalArticlepeer-review

Abstract

The isotopic antiglobulin test modified for use with tissue culture cellsgrown as adherent monolayers resulted in aquick, sensitive microassay. Serum, prepared from blood of mice hyperimmunizedwith a syngeneic C57BL/6N tumor inducedby 3-methylcholanthrene (MCA) in vitro, cross-reacted with 3 of 7 different MCA-induced tumors. After absorption of serum, the activity was blocked by all MCA-inducedtumor lines and a normal fibroblast line, butnot by normal spleen cells. There was a weakcross-reactivity with murine Moloney andGross virus-induced tumors. A similar weakreactivity with C57BL/6N multiparous exbreeder serum indicated a possible relationship to fetal antigen.

Original languageEnglish (US)
Pages (from-to)1149-1156
Number of pages8
JournalJournal of the National Cancer Institute
Volume51
Issue number4
DOIs
StatePublished - Oct 1973
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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