Cross reactive T cell antigens among mammalian species

C. M. Balch, M. K. Dagg, M. D. Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

Fluoresceinated heteroantisera prepared against T cells of rats, monkeys, and humans were reacted with thymus and spleen cells from 11 selected species. These reagents recognized cross reacting T cell antigen(s) among rodent species (mouse, rat, guinea pig, and hamster) and among primate species (monkey and humans). With one exception, the cross reactivity was restricted to a phylogenetic order. All 3 antisera required relatively few absorptions to achieve T cell specificity for related species when compared to absorption requirements for the isologous species. Differentiation antigens within a phylogenetic order thus appear to be more homologous than other cell surface constituents on T cells.

Original languageEnglish (US)
Pages (from-to)447-449
Number of pages3
JournalJournal of Immunology
Volume117
Issue number2
StatePublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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