Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities

Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, Paul A. Goepfert

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccines designed to bring forth CD8+ T cell responses in different racial and ethnic groups will require inclusion of T cell epitopes presented by various MHC class I molecules. This study was designed to identify new CD8+ T cell epitopes in HIV-infected African American and Hispanic youth as well as to determine the frequency of responses to both novel and previously described HIV-1 epitopes in a cohort of racially and ethnically diverse individuals. We found 8 MHC class I-restricted CD8+ T cell epitopes that had not been previously described, another 8 epitopes that were restricted by class I alleles not previously associated with these epitopes, and 8 additional epitopes that have been described previously. In a larger cohort, we demonstrated that 11 (69%) of these 16 newly described immunogens were recognized by individuals of different race or ethnicity. Most HIV-1-specific CD8+ T cell epitopes identified were either novel or restricted by alternative MHC class I alleles. Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine.

Original languageEnglish (US)
Pages (from-to)426-438
Number of pages13
JournalJournal of acquired immune deficiency syndromes
Volume33
Issue number4
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • CD8 T cell responses
  • CTL epitopes
  • CTL vaccines
  • Class I restriction
  • HIV vaccine

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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