Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial

J. D. Clemens, D. A. Sack, J. R. Harris, J. Chakraborty, P. K. Neogy, B. Stanton, N. Huda, M. U. Khan, B. A. Kay, M. R. Khan, M. Ansaruzzaman, M. Yunus, M. R. Rao, A. M. Svennerholm, J. Holmgren

Research output: Contribution to journalArticle

Abstract

The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are genetically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P <.01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P <.05).

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalJournal of Infectious Diseases
Volume158
Issue number2
StatePublished - 1988
Externally publishedYes

Fingerprint

Cholera Vaccines
Cross Protection
Enterotoxigenic Escherichia coli
Diarrhea
Hot Temperature
Cholera Toxin
Enterotoxins
Dehydration
Vaccines

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli : Results of a large-scale field trial. / Clemens, J. D.; Sack, D. A.; Harris, J. R.; Chakraborty, J.; Neogy, P. K.; Stanton, B.; Huda, N.; Khan, M. U.; Kay, B. A.; Khan, M. R.; Ansaruzzaman, M.; Yunus, M.; Rao, M. R.; Svennerholm, A. M.; Holmgren, J.

In: Journal of Infectious Diseases, Vol. 158, No. 2, 1988, p. 372-377.

Research output: Contribution to journalArticle

Clemens, JD, Sack, DA, Harris, JR, Chakraborty, J, Neogy, PK, Stanton, B, Huda, N, Khan, MU, Kay, BA, Khan, MR, Ansaruzzaman, M, Yunus, M, Rao, MR, Svennerholm, AM & Holmgren, J 1988, 'Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial', Journal of Infectious Diseases, vol. 158, no. 2, pp. 372-377.
Clemens, J. D. ; Sack, D. A. ; Harris, J. R. ; Chakraborty, J. ; Neogy, P. K. ; Stanton, B. ; Huda, N. ; Khan, M. U. ; Kay, B. A. ; Khan, M. R. ; Ansaruzzaman, M. ; Yunus, M. ; Rao, M. R. ; Svennerholm, A. M. ; Holmgren, J. / Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli : Results of a large-scale field trial. In: Journal of Infectious Diseases. 1988 ; Vol. 158, No. 2. pp. 372-377.
@article{72ed1c31e20e421e92acd9251cf0a85a,
title = "Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial",
abstract = "The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are genetically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P <.01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86{\%}; P <.05).",
author = "Clemens, {J. D.} and Sack, {D. A.} and Harris, {J. R.} and J. Chakraborty and Neogy, {P. K.} and B. Stanton and N. Huda and Khan, {M. U.} and Kay, {B. A.} and Khan, {M. R.} and M. Ansaruzzaman and M. Yunus and Rao, {M. R.} and Svennerholm, {A. M.} and J. Holmgren",
year = "1988",
language = "English (US)",
volume = "158",
pages = "372--377",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli

T2 - Results of a large-scale field trial

AU - Clemens, J. D.

AU - Sack, D. A.

AU - Harris, J. R.

AU - Chakraborty, J.

AU - Neogy, P. K.

AU - Stanton, B.

AU - Huda, N.

AU - Khan, M. U.

AU - Kay, B. A.

AU - Khan, M. R.

AU - Ansaruzzaman, M.

AU - Yunus, M.

AU - Rao, M. R.

AU - Svennerholm, A. M.

AU - Holmgren, J.

PY - 1988

Y1 - 1988

N2 - The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are genetically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P <.01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P <.05).

AB - The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are genetically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P <.01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P <.05).

UR - http://www.scopus.com/inward/record.url?scp=0023675994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023675994&partnerID=8YFLogxK

M3 - Article

C2 - 3042876

AN - SCOPUS:0023675994

VL - 158

SP - 372

EP - 377

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -