Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial

J. D. Clemens, D. A. Sack, J. R. Harris, J. Chakraborty, P. K. Neogy, B. Stanton, N. Huda, M. U. Khan, B. A. Kay, M. R. Khan, M. Ansaruzzaman, M. Yunus, M. R. Rao, A. M. Svennerholm, J. Holmgren

Research output: Contribution to journalArticle

Abstract

The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are genetically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P < .01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P < .05).

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalJournal of Infectious Diseases
Volume158
Issue number2
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Clemens, J. D., Sack, D. A., Harris, J. R., Chakraborty, J., Neogy, P. K., Stanton, B., Huda, N., Khan, M. U., Kay, B. A., Khan, M. R., Ansaruzzaman, M., Yunus, M., Rao, M. R., Svennerholm, A. M., & Holmgren, J. (1988). Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial. Journal of Infectious Diseases, 158(2), 372-377. https://doi.org/10.1093/infdis/158.2.372