Cross-presentation of peptides from intracellular pathogens by MHC class i molecules

Nicolas Blanchard, Nilabh Shastri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many prokaryotic and eukaryotic parasites multiply in specialized subcellular niches in the host cell. The invading microbes hijack key cellular functions to establish the intracellular niches but, unlike viruses, do not need the protein synthesis machinery of host cells to replicate. Circulating CD8+ T cells provide protective immunity by recognizing pathogen-derived peptide major histocompatibility complex class I molecules (pMHC I) expressed by infected cells. Here, we review studies on the complex and varied pathways that produce the appropriate pMHC I as ligands for the CD8 + T cells. We also discuss possible explanations for the curious observations that CD8+ T cells are specific for fewer pMHC I ligands in parasite infections compared to the diversity of pMHC I ligands in viral infections.

Original languageEnglish (US)
Title of host publicationThe Year in Immunology 2
PublisherBlackwell Publishing Inc.
Pages237-250
Number of pages14
ISBN (Print)9781573317795
DOIs
StatePublished - Jan 10 2010
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1183
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antigen
  • Bacteria
  • Cross-presentation
  • Parasite
  • Virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Blanchard, N., & Shastri, N. (2010). Cross-presentation of peptides from intracellular pathogens by MHC class i molecules. In The Year in Immunology 2 (pp. 237-250). (Annals of the New York Academy of Sciences; Vol. 1183). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05135.x