Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience

Anubhuthi Goel, Bin Jiang, Linda W. Xu, Lihua Song, Alfredo Kirkwood, Hey Kyoung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.

Original languageEnglish (US)
Pages (from-to)1001-1003
Number of pages3
JournalNature neuroscience
Volume9
Issue number8
DOIs
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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