Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience

Anubhuthi Goel; Bin Jiang; Linda W. Xu; Lihua Song; Alfredo Kirkwood; Hey Kyoung Lee

doi:10.1038/nn1725

Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience

Anubhuthi Goel, Bin Jiang, Linda W. Xu, Lihua Song, Alfredo Kirkwood, Hey Kyoung Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.

Original language	English (US)
Pages (from-to)	1001-1003
Number of pages	3
Journal	Nature neuroscience
Volume	9
Issue number	8
DOIs	https://doi.org/10.1038/nn1725
State	Published - Aug 2006

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nn1725

Cite this

@article{ea430d343dba4eaeba360f88ff3b2137,

title = "Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience",

abstract = "Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.",

author = "Anubhuthi Goel and Bin Jiang and Xu, {Linda W.} and Lihua Song and Alfredo Kirkwood and Lee, {Hey Kyoung}",

note = "Funding Information: The authors would like to thank E.M. Quinlan for helpful discussions and comments on this manuscript. This work was supported by a US National Institutes of Health grant (R01-EY014882) and a Sloan Research Fellowship to H.-K.L., a US National Institutes of Health grant (R01-EY012124) to A.K. and a Howard Hughes Medical Institute Undergraduate Research Fellowship to L.W.X.",

year = "2006",

month = aug,

doi = "10.1038/nn1725",

language = "English (US)",

volume = "9",

pages = "1001--1003",

journal = "Nature neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "8",

}

TY - JOUR

T1 - Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience

AU - Goel, Anubhuthi

AU - Jiang, Bin

AU - Xu, Linda W.

AU - Song, Lihua

AU - Kirkwood, Alfredo

AU - Lee, Hey Kyoung

N1 - Funding Information: The authors would like to thank E.M. Quinlan for helpful discussions and comments on this manuscript. This work was supported by a US National Institutes of Health grant (R01-EY014882) and a Sloan Research Fellowship to H.-K.L., a US National Institutes of Health grant (R01-EY012124) to A.K. and a Howard Hughes Medical Institute Undergraduate Research Fellowship to L.W.X.

PY - 2006/8

Y1 - 2006/8

N2 - Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.

AB - Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.

UR - http://www.scopus.com/inward/record.url?scp=33747598065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747598065&partnerID=8YFLogxK

U2 - 10.1038/nn1725

DO - 10.1038/nn1725

M3 - Article

C2 - 16819524

AN - SCOPUS:33747598065

SN - 1097-6256

VL - 9

SP - 1001

EP - 1003

JO - Nature neuroscience

JF - Nature neuroscience

IS - 8

ER -

Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this