Cross-linking of lens crystallins in a photodynamic system: A process mediated by singlet oxygen

John D. Goosey; J. Samuel Zigler; Jin H. Kinoshita

doi:10.1126/science.7375939

Cross-linking of lens crystallins in a photodynamic system: A process mediated by singlet oxygen

John D. Goosey, J. Samuel Zigler, Jin H. Kinoshita

School of Medicine

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

In a dye-sensitized photooxidation system, lens cry stallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.

Original language	English (US)
Pages (from-to)	1278-1280
Number of pages	3
Journal	Science
Volume	208
Issue number	4449
DOIs	https://doi.org/10.1126/science.7375939
State	Published - Jan 1 1980

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title = "Cross-linking of lens crystallins in a photodynamic system: A process mediated by singlet oxygen",

abstract = "In a dye-sensitized photooxidation system, lens cry stallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.",

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N2 - In a dye-sensitized photooxidation system, lens cry stallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.

AB - In a dye-sensitized photooxidation system, lens cry stallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.

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Cross-linking of lens crystallins in a photodynamic system: A process mediated by singlet oxygen

Abstract

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