Abstract
An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.
Original language | English (US) |
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Pages (from-to) | 135-139 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 42 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2006 |
Externally published | Yes |
Keywords
- Cell-mediated immunity
- HIV
- Viral clade
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)