Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon

Swati B. Gupta, Christopher T. Mast, Nathan D. Wolfe, Vlad Novitsky, Sheri A. Dubey, Esper G. Kallas, Mauro Schechter, Bernard Mbewe, Eftyhia Vardas, Punee Pitisuttithum, Donald Burke, Dan Freed, Robin Mogg, Paul M. Coplan, Jon H. Condra, Romnie S. Long, Kiersten Anderson, Danilo R. Casimiro, John W. Shiver, Walter L. Straus

Research output: Contribution to journalArticlepeer-review

Abstract

An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalJournal of acquired immune deficiency syndromes
Volume42
Issue number2
DOIs
StatePublished - Jun 2006

Keywords

  • Cell-mediated immunity
  • HIV
  • Viral clade

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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