Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma

Christopher W. Valle, Taehong Min, Manish Bodas, Steven Mazur, Shahnaz Begum, Danni Tang, Neeraj Vij

Research output: Contribution to journalArticle

Abstract

Background: Valosin-containing protein (VCP)/p97 is an AAA ATPase molecular chaperone that regulates vital cellular functions and protein-processing. A recent study indicated that VCP expression levels are correlated with prognosis and progression of non-small cell lung carcinoma (NSCLC). We not only verified these findings but also identified the specific role of VCP in NSCLC pathogenesis and progression. Methodology/Principal Findings: Our results show that VCP is significantly overexpressed in non-small cell lung carcinoma (NSCLC) as compared to normal tissues and cell lines (p

Original languageEnglish (US)
Article numbere29073
JournalPLoS One
Volume6
Issue number12
DOIs
StatePublished - Dec 22 2011

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Valle, C. W., Min, T., Bodas, M., Mazur, S., Begum, S., Tang, D., & Vij, N. (2011). Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma. PLoS One, 6(12), [e29073]. https://doi.org/10.1371/journal.pone.0029073