Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Shasha Liu, Yuan Liao, Biao Chen, Yuhai Chen, Ziding Yu, Haitao Wei, Lianfeng Zhang, Shile Huang, Paul B. Rothman, George Fu Gao, Ji Long Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Liu et al. describe a role of Syk-dependent STAT1 activation in innate antiviral immunity. Initial activation of STAT1 during IAV infection is regulated by RIG-I/MAVS/Syk signaling. Additionally, STAT1 Tyr-701 is a critical residue for the antiviral response. Conditional Syk knockout and STAT1 Y701F knockin mouse models corroborate these findings.

Original languageEnglish (US)
Article number108627
JournalCell Reports
Volume34
Issue number3
DOIs
StatePublished - Jan 19 2021

Keywords

  • MAVS
  • RIG-I
  • STAT1
  • Syk
  • cytokine
  • influenza virus
  • innate immunity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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