Periodos críticos de plasticidad cortical

Translated title of the contribution: Critical period of cortical plasticity

B. Morales, C. Rozas, F. Pancetti, Alfredo Kirkwood

Research output: Contribution to journalReview articlepeer-review


Introduction and development. Alterations of sensory experience cause large-scale re-arrangements of cortical connectivity only early in life. After a critical period that roughly ends by puberty, comparable modifications requires more invasive manipulations, including deafferentation and cortical lesions. At a cellular level, the elementary mechanisms responsible for synaptic modification appear to be available throughout life. Thus, in adults, experience dependent plasticity might be constrained additional factors, like the maturation of inhibition or changes in the extra cellular matrix. Such view is consistent with a limited, but not absent, modifiability of adult cortical circuits. This view also has interesting therapeutical implications. Conclusion. In this scenario, manipulation of these limiting factors, for example reducing synaptic inhibition, might be a useful strategy to enhance plasticity and to restore function in the adult cortex.

Translated title of the contributionCritical period of cortical plasticity
Original languageSpanish
Pages (from-to)739-743
Number of pages5
JournalRevista de Neurologia
Issue number8
StatePublished - Oct 16 2003
Externally publishedYes


  • Critical period
  • LTD
  • LTP
  • Neocortex
  • Synaptic plasticity

ASJC Scopus subject areas

  • Clinical Neurology


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