Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma

Timothy M. Pawlik; Ronnie T. Poon; Eddie K. Abdalla; Daria Zorzi; Iwao Ikai; Steven A. Curley; David M. Nagorney; Jacques Belghiti; Irene Oi-Lin Ng; Yoshio Yamaoka; Gregory Y. Lauwers; Jean Nicolas Vauthey; John Brems; Burr Ridee; Scott Helton; Anton Bilchik; William Chapman

doi:10.1001/archsurg.140.5.450

Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma

Timothy M. Pawlik, Ronnie T. Poon, Eddie K. Abdalla, Daria Zorzi, Iwao Ikai, Steven A. Curley, David M. Nagorney, Jacques Belghiti, Irene Oi-Lin Ng, Yoshio Yamaoka, Gregory Y. Lauwers, Jean Nicolas Vauthey, John Brems, Burr Ridee, Scott Helton, Anton Bilchik, William Chapman

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

Hypothesis: A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design: Retrospective study of a multi-institutional database. Setting: Five major hepatobiliary centers. Patients: We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. Main Outcome Measures: Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. Results: The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-α-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P

Original language	English (US)
Pages (from-to)	450-458
Number of pages	9
Journal	Archives of Surgery
Volume	140
Issue number	5
DOIs	https://doi.org/10.1001/archsurg.140.5.450
State	Published - May 2005
Externally published	Yes

ASJC Scopus subject areas

Surgery

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Pawlik, T. M., Poon, R. T., Abdalla, E. K., Zorzi, D., Ikai, I., Curley, S. A., Nagorney, D. M., Belghiti, J., Oi-Lin Ng, I., Yamaoka, Y., Lauwers, G. Y., Vauthey, J. N., Brems, J., Ridee, B., Helton, S., Bilchik, A., & Chapman, W. (2005). Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Archives of Surgery, 140(5), 450-458. https://doi.org/10.1001/archsurg.140.5.450

Pawlik, TM, Poon, RT, Abdalla, EK, Zorzi, D, Ikai, I, Curley, SA, Nagorney, DM, Belghiti, J, Oi-Lin Ng, I, Yamaoka, Y, Lauwers, GY, Vauthey, JN, Brems, J, Ridee, B, Helton, S, Bilchik, A & Chapman, W 2005, 'Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma', Archives of Surgery, vol. 140, no. 5, pp. 450-458. https://doi.org/10.1001/archsurg.140.5.450

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title = "Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma",

abstract = "Hypothesis: A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design: Retrospective study of a multi-institutional database. Setting: Five major hepatobiliary centers. Patients: We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. Main Outcome Measures: Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. Results: The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-α-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P",

author = "Pawlik, {Timothy M.} and Poon, {Ronnie T.} and Abdalla, {Eddie K.} and Daria Zorzi and Iwao Ikai and Curley, {Steven A.} and Nagorney, {David M.} and Jacques Belghiti and {Oi-Lin Ng}, Irene and Yoshio Yamaoka and Lauwers, {Gregory Y.} and Vauthey, {Jean Nicolas} and John Brems and Burr Ridee and Scott Helton and Anton Bilchik and William Chapman",

year = "2005",

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doi = "10.1001/archsurg.140.5.450",

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T1 - Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma

AU - Pawlik, Timothy M.

AU - Poon, Ronnie T.

AU - Abdalla, Eddie K.

AU - Zorzi, Daria

AU - Ikai, Iwao

AU - Curley, Steven A.

AU - Nagorney, David M.

AU - Belghiti, Jacques

AU - Oi-Lin Ng, Irene

AU - Yamaoka, Yoshio

AU - Lauwers, Gregory Y.

AU - Vauthey, Jean Nicolas

AU - Brems, John

AU - Ridee, Burr

AU - Helton, Scott

AU - Bilchik, Anton

AU - Chapman, William

PY - 2005/5

Y1 - 2005/5

N2 - Hypothesis: A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design: Retrospective study of a multi-institutional database. Setting: Five major hepatobiliary centers. Patients: We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. Main Outcome Measures: Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. Results: The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-α-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P

AB - Hypothesis: A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design: Retrospective study of a multi-institutional database. Setting: Five major hepatobiliary centers. Patients: We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. Main Outcome Measures: Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. Results: The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-α-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P

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Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma

Abstract

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