Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma

Timothy M. Pawlik, Ronnie T. Poon, Eddie K. Abdalla, Daria Zorzi, Iwao Ikai, Steven A. Curley, David M. Nagorney, Jacques Belghiti, Irene Oi-Lin Ng, Yoshio Yamaoka, Gregory Y. Lauwers, Jean Nicolas Vauthey, John Brems, Burr Ridee, Scott Helton, Anton Bilchik, William Chapman

Research output: Contribution to journalArticle

Abstract

Hypothesis: A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design: Retrospective study of a multi-institutional database. Setting: Five major hepatobiliary centers. Patients: We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. Main Outcome Measures: Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. Results: The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-α-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P

Original languageEnglish (US)
Pages (from-to)450-458
Number of pages9
JournalArchives of Surgery
Volume140
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Pawlik, T. M., Poon, R. T., Abdalla, E. K., Zorzi, D., Ikai, I., Curley, S. A., Nagorney, D. M., Belghiti, J., Oi-Lin Ng, I., Yamaoka, Y., Lauwers, G. Y., Vauthey, J. N., Brems, J., Ridee, B., Helton, S., Bilchik, A., & Chapman, W. (2005). Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Archives of Surgery, 140(5), 450-458. https://doi.org/10.1001/archsurg.140.5.450