Critical appraisal of loteprednol ointment, gel, and suspension in the treatment of postoperative inflammation and pain following ocular and corneal transplant surgery

Amir Pirouzian, Earl Randy Craven

Research output: Contribution to journalArticle

Abstract

Purpose: To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery. Methods: We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery. Results: A total of 59 peer-reviewed articles were found in the literature. The focus of the majority of the articles was on the safety and efficacy of loteprednol etabonate 0.5% in post-operative control of inflammation and pain following cataract surgery. There were only three articles with a remote association between loteprednol etabonate and keratoplasty. Conclusion: Lotemax® ointment may also have potential as a first-line anti-inflammatory agent of choice in postoperative settings of strabismus and penetrating glaucoma, and following low-risk penetrating keratoplasty procedures.

Original languageEnglish (US)
Pages (from-to)379-387
Number of pages9
JournalClinical Ophthalmology
Volume8
DOIs
StatePublished - Feb 10 2014

Fingerprint

Postoperative Pain
Ointments
Suspensions
Gels
Inflammation
Transplants
Eye Pain
Therapeutics
Penetrating Keratoplasty
Corneal Transplantation
Strabismus
PubMed
Glaucoma
Cataract
Anti-Inflammatory Agents
Loteprednol Etabonate
Safety
Pain

Keywords

  • Eye
  • Inflammation
  • Keratoplasty
  • Loteprednol
  • Pain
  • Surgery

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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abstract = "Purpose: To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery. Methods: We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery. Results: A total of 59 peer-reviewed articles were found in the literature. The focus of the majority of the articles was on the safety and efficacy of loteprednol etabonate 0.5{\%} in post-operative control of inflammation and pain following cataract surgery. There were only three articles with a remote association between loteprednol etabonate and keratoplasty. Conclusion: Lotemax{\circledR} ointment may also have potential as a first-line anti-inflammatory agent of choice in postoperative settings of strabismus and penetrating glaucoma, and following low-risk penetrating keratoplasty procedures.",
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N2 - Purpose: To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery. Methods: We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery. Results: A total of 59 peer-reviewed articles were found in the literature. The focus of the majority of the articles was on the safety and efficacy of loteprednol etabonate 0.5% in post-operative control of inflammation and pain following cataract surgery. There were only three articles with a remote association between loteprednol etabonate and keratoplasty. Conclusion: Lotemax® ointment may also have potential as a first-line anti-inflammatory agent of choice in postoperative settings of strabismus and penetrating glaucoma, and following low-risk penetrating keratoplasty procedures.

AB - Purpose: To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery. Methods: We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery. Results: A total of 59 peer-reviewed articles were found in the literature. The focus of the majority of the articles was on the safety and efficacy of loteprednol etabonate 0.5% in post-operative control of inflammation and pain following cataract surgery. There were only three articles with a remote association between loteprednol etabonate and keratoplasty. Conclusion: Lotemax® ointment may also have potential as a first-line anti-inflammatory agent of choice in postoperative settings of strabismus and penetrating glaucoma, and following low-risk penetrating keratoplasty procedures.

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