Abstract
The urinary excretion method and the constant infusion technique were used to estimate hFSH production rates (PR) in three normal men (aged 25-40 years). Both studies were also done in a hypophysectomized nine year old boy. The PR of hFSH in the urinary excretion studies ranged from 20.0 to 45.7 IU/24 h, whereas the constant infusion studies yielded PR's of 68.7 to 107.8 IU/24 h. Possible reasons for the discrepancy of the results obtained by the two methods are discussed. In the hypophysectomized patient, the metabolic clearance rate (MCR) of infused hFSH was much lower (4.3 ml/min) than in the normal adults (7.8 to 12.0 ml/min) and was not affected by the dose of hFSH given.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 275-283 |
| Number of pages | 9 |
| Journal | Acta Endocrinologica |
| Volume | 80 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
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Critical analysis of methods for estimating production rates of FSH. / Raiti, S.; Blizzard, R. M.; Penny, R.; Migeon, C. J.
In: Acta Endocrinologica, Vol. 80, No. 2, 1975, p. 275-283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Critical analysis of methods for estimating production rates of FSH
AU - Raiti, S.
AU - Blizzard, R. M.
AU - Penny, R.
AU - Migeon, C. J.
PY - 1975
Y1 - 1975
N2 - The urinary excretion method and the constant infusion technique were used to estimate hFSH production rates (PR) in three normal men (aged 25-40 years). Both studies were also done in a hypophysectomized nine year old boy. The PR of hFSH in the urinary excretion studies ranged from 20.0 to 45.7 IU/24 h, whereas the constant infusion studies yielded PR's of 68.7 to 107.8 IU/24 h. Possible reasons for the discrepancy of the results obtained by the two methods are discussed. In the hypophysectomized patient, the metabolic clearance rate (MCR) of infused hFSH was much lower (4.3 ml/min) than in the normal adults (7.8 to 12.0 ml/min) and was not affected by the dose of hFSH given.
AB - The urinary excretion method and the constant infusion technique were used to estimate hFSH production rates (PR) in three normal men (aged 25-40 years). Both studies were also done in a hypophysectomized nine year old boy. The PR of hFSH in the urinary excretion studies ranged from 20.0 to 45.7 IU/24 h, whereas the constant infusion studies yielded PR's of 68.7 to 107.8 IU/24 h. Possible reasons for the discrepancy of the results obtained by the two methods are discussed. In the hypophysectomized patient, the metabolic clearance rate (MCR) of infused hFSH was much lower (4.3 ml/min) than in the normal adults (7.8 to 12.0 ml/min) and was not affected by the dose of hFSH given.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016826631&partnerID=8YFLogxK
M3 - Article
C2 - 1242268
AN - SCOPUS:0016826631
VL - 80
SP - 275
EP - 283
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 2
ER -