Abstract
A 28-YEAR-OLD WOMAN with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.
Original language | English (US) |
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Pages (from-to) | 737-740 |
Number of pages | 4 |
Journal | Neurosurgery |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1994 |
Externally published | Yes |
Keywords
- Creutzfeldt-jakob syndrome
- Dura mater
- Neurosurgery
- Pregnancy
- Prion diseases
- Spongiform encephalopathies
- Tissue grafting
ASJC Scopus subject areas
- Surgery
- Clinical Neurology