Creutzfeldt-jakob disease in a pregnant woman with an implanted dura mater graft

Kathryn L. Lane, Paul Brown, David N. Howell, Barbara J. Crain, Christine M. Hulette, Peter C. Burger, Stephen J. Dearmond

Research output: Contribution to journalArticle

Abstract

A 28-YEAR-OLD WOMAN with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalNeurosurgery
Volume34
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • Creutzfeldt-jakob syndrome
  • Dura mater
  • Neurosurgery
  • Pregnancy
  • Prion diseases
  • Spongiform encephalopathies
  • Tissue grafting

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Lane, K. L., Brown, P., Howell, D. N., Crain, B. J., Hulette, C. M., Burger, P. C., & Dearmond, S. J. (1994). Creutzfeldt-jakob disease in a pregnant woman with an implanted dura mater graft. Neurosurgery, 34(4), 737-740. https://doi.org/10.1227/00006123-199404000-00026