TY - JOUR
T1 - Creation of a biological pacemaker by gene- or cell-based approaches
AU - Marbán, Eduardo
AU - Cho, Hee Cheol
PY - 2007/2
Y1 - 2007/2
N2 - Cardiac rhythm-associated disorders are caused by mal-functions of impulse generation and conduction. Present therapies for the impulse generation span a wide array of approaches but remain largely palliative. The progress in the understanding of the biology of the diseases with related biological tools beckons for new approaches to provide better alternatives to the present routine. Here, we review the current state of the art in gene- and cell-based approaches to correct cardiac rhythm disturbances. These include genetic suppression of an ionic current, stem cell therapies, adult somatic cell-fusion approach, novel synthetic pacemaker channel, and creating a self-contained pacemaker activity in non-excitable cells. We then conclude by discussing advantages and disadvantages of the new possibilities.
AB - Cardiac rhythm-associated disorders are caused by mal-functions of impulse generation and conduction. Present therapies for the impulse generation span a wide array of approaches but remain largely palliative. The progress in the understanding of the biology of the diseases with related biological tools beckons for new approaches to provide better alternatives to the present routine. Here, we review the current state of the art in gene- and cell-based approaches to correct cardiac rhythm disturbances. These include genetic suppression of an ionic current, stem cell therapies, adult somatic cell-fusion approach, novel synthetic pacemaker channel, and creating a self-contained pacemaker activity in non-excitable cells. We then conclude by discussing advantages and disadvantages of the new possibilities.
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U2 - 10.1007/s11517-007-0165-2
DO - 10.1007/s11517-007-0165-2
M3 - Review article
C2 - 17262203
AN - SCOPUS:33847143196
SN - 0140-0118
VL - 45
SP - 133
EP - 144
JO - Medical and Biological Engineering and Computing
JF - Medical and Biological Engineering and Computing
IS - 2
ER -