Creation of a biological pacemaker by gene- or cell-based approaches

Eduardo Marbán, Hee Cheol Cho

Research output: Contribution to journalArticle

Abstract

Cardiac rhythm-associated disorders are caused by mal-functions of impulse generation and conduction. Present therapies for the impulse generation span a wide array of approaches but remain largely palliative. The progress in the understanding of the biology of the diseases with related biological tools beckons for new approaches to provide better alternatives to the present routine. Here, we review the current state of the art in gene- and cell-based approaches to correct cardiac rhythm disturbances. These include genetic suppression of an ionic current, stem cell therapies, adult somatic cell-fusion approach, novel synthetic pacemaker channel, and creating a self-contained pacemaker activity in non-excitable cells. We then conclude by discussing advantages and disadvantages of the new possibilities.

Original languageEnglish (US)
Pages (from-to)133-144
Number of pages12
JournalMedical & Biological Engineering & Computing
Volume45
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management
  • Computer Science Applications
  • Computational Theory and Mathematics

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