Creatine increases survival and delays motor symptoms in a transgenic animal model of Huntington's disease

O. A. Andreassen, A. Dedeoglu, R. J. Ferrante, B. G. Jenkins, K. L. Ferrante, M. Thomas, A. Friedlich, S. E. Browne, G. Schilling, D. R. Borchelt, S. M. Hersch, C. A. Ross, M. F. Beal

Research output: Contribution to journalArticle

Abstract

There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition. We examined the effects of creatine administration in a transgenic mouse model of HD produced by 82 polyglutamine repeats in a 171 amino acid N-terminal fragment of huntingtin (N171-82Q). Dietary supplementation of 2% creatine significantly improved survival, slowed the development of motor symptoms, and delayed the onset of weight loss. Creatine lessened brain atrophy and the formation of intranuclear inclusions, attenuated reductions in striatal N-acetylaspartate as assessed by NMR spectroscopy, and delayed the development of hyperglycemia. These results are similar to those observed using dietary creatine supplementation in the R6/2 transgenic mouse model of HD and provide further evidence that creatine may exert therapeutic effects in HD.

Original languageEnglish (US)
Pages (from-to)479-491
Number of pages13
JournalNeurobiology of Disease
Volume8
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Creatine
  • Diabetes
  • Huntington's
  • N-acetylaspartate
  • NMR spectroscopy
  • Transgenic

ASJC Scopus subject areas

  • Neurology

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    Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., Hersch, S. M., Ross, C. A., & Beal, M. F. (2001). Creatine increases survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of Disease, 8(3), 479-491. https://doi.org/10.1006/nbdi.2001.0406