Abstract
Introduction: The subjective experience of drug craving is a prominent and common clinical phenomenon for many individuals diagnosed with opioid use disorder (OUD), and could be a valuable clinical endpoint in medication development studies. The purpose of this scoping review is to provide an overview and critical analysis of opioid craving assessments located in the published literature examining OUD. Method: Studies were identified through a search of PubMed, Embase, and PsychInfo databases and included for review if opioid craving was the focus and participants were diagnosed with or in treatment for OUD. Results: Fifteen opioid craving assessment instruments were identified across the 87 studies included for review. The most common were the Visual Analog Scale (VAS, 41 studies), Desires for Drug Questionnaire (DDQ, 12 studies), Heroin Craving Questionnaire (HCQ, 10 studies), and Obsessive-Compulsive Drug Use Scale (OCDUS, 10 studies). Craving assessments varied considerably in their format, content, time frame, and underlying subscales, and only 6 of 15 had been psychometrically evaluated. Discussion: This review identified a variety of opioid craving assessments, but few had been evaluated for their psychometric properties making it difficult to ascertain whether craving is being assessed optimally in studies of OUD. Thus, the development of a reliable and valid opioid craving assessment would be worthwhile and could be guided by recently published Food and Drug Administration Clinical Outcome Assessment (COA) guidelines. Importantly, a COA focused on opioid craving could be a valuable addition to research studies designed to evaluate novel treatments for OUD.
| Original language | English (US) |
|---|---|
| Article number | 107639 |
| Journal | Drug and alcohol dependence |
| Volume | 205 |
| DOIs | |
| State | Published - Dec 1 2019 |
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Keywords
- Craving
- Dependence
- Opioid
- Opioid use disorder
- Outcomes
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Psychiatry and Mental health
- Pharmacology (medical)
Cite this
Craving and opioid use disorder : A scoping review. / Kleykamp, Bethea A.; De Santis, Marta; Dworkin, Robert H.; Huhn, Andrew S.; Kampman, Kyle M.; Montoya, Ivan D.; Preston, Kenzie L.; Ramey, Tanya; Smith, Shannon M.; Turk, Dennis C.; Walsh, Robert; Weiss, Roger D.; Strain, Eric C.
In: Drug and alcohol dependence, Vol. 205, 107639, 01.12.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Craving and opioid use disorder
T2 - A scoping review
AU - Kleykamp, Bethea A.
AU - De Santis, Marta
AU - Dworkin, Robert H.
AU - Huhn, Andrew S.
AU - Kampman, Kyle M.
AU - Montoya, Ivan D.
AU - Preston, Kenzie L.
AU - Ramey, Tanya
AU - Smith, Shannon M.
AU - Turk, Dennis C.
AU - Walsh, Robert
AU - Weiss, Roger D.
AU - Strain, Eric C.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Introduction: The subjective experience of drug craving is a prominent and common clinical phenomenon for many individuals diagnosed with opioid use disorder (OUD), and could be a valuable clinical endpoint in medication development studies. The purpose of this scoping review is to provide an overview and critical analysis of opioid craving assessments located in the published literature examining OUD. Method: Studies were identified through a search of PubMed, Embase, and PsychInfo databases and included for review if opioid craving was the focus and participants were diagnosed with or in treatment for OUD. Results: Fifteen opioid craving assessment instruments were identified across the 87 studies included for review. The most common were the Visual Analog Scale (VAS, 41 studies), Desires for Drug Questionnaire (DDQ, 12 studies), Heroin Craving Questionnaire (HCQ, 10 studies), and Obsessive-Compulsive Drug Use Scale (OCDUS, 10 studies). Craving assessments varied considerably in their format, content, time frame, and underlying subscales, and only 6 of 15 had been psychometrically evaluated. Discussion: This review identified a variety of opioid craving assessments, but few had been evaluated for their psychometric properties making it difficult to ascertain whether craving is being assessed optimally in studies of OUD. Thus, the development of a reliable and valid opioid craving assessment would be worthwhile and could be guided by recently published Food and Drug Administration Clinical Outcome Assessment (COA) guidelines. Importantly, a COA focused on opioid craving could be a valuable addition to research studies designed to evaluate novel treatments for OUD.
AB - Introduction: The subjective experience of drug craving is a prominent and common clinical phenomenon for many individuals diagnosed with opioid use disorder (OUD), and could be a valuable clinical endpoint in medication development studies. The purpose of this scoping review is to provide an overview and critical analysis of opioid craving assessments located in the published literature examining OUD. Method: Studies were identified through a search of PubMed, Embase, and PsychInfo databases and included for review if opioid craving was the focus and participants were diagnosed with or in treatment for OUD. Results: Fifteen opioid craving assessment instruments were identified across the 87 studies included for review. The most common were the Visual Analog Scale (VAS, 41 studies), Desires for Drug Questionnaire (DDQ, 12 studies), Heroin Craving Questionnaire (HCQ, 10 studies), and Obsessive-Compulsive Drug Use Scale (OCDUS, 10 studies). Craving assessments varied considerably in their format, content, time frame, and underlying subscales, and only 6 of 15 had been psychometrically evaluated. Discussion: This review identified a variety of opioid craving assessments, but few had been evaluated for their psychometric properties making it difficult to ascertain whether craving is being assessed optimally in studies of OUD. Thus, the development of a reliable and valid opioid craving assessment would be worthwhile and could be guided by recently published Food and Drug Administration Clinical Outcome Assessment (COA) guidelines. Importantly, a COA focused on opioid craving could be a valuable addition to research studies designed to evaluate novel treatments for OUD.
KW - Craving
KW - Dependence
KW - Opioid
KW - Opioid use disorder
KW - Outcomes
UR - http://www.scopus.com/inward/record.url?scp=85074194091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074194091&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2019.107639
DO - 10.1016/j.drugalcdep.2019.107639
M3 - Review article
C2 - 31683241
AN - SCOPUS:85074194091
VL - 205
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
M1 - 107639
ER -