Craniopharyngiomas

Radiological differentiation of two types

In Ho Lee, Elcin Zan, W. Robert Bell, Peter C. Burger, Heejong Sung, David Mark Yousem

Research output: Contribution to journalArticle

Abstract

Objective: To determine imaging features that may separate adamantinomatous and papillary variants of craniopharyngiomas given that tumors with adamantinomatous signature features are associated with higher recurrence rates, morbidity, and mortality. We specifically reviewed calcification on CT, T1 bright signal intensity, and cystic change on T2 weighted images for differentiating these two types. Methods: We retrospectively reviewed the MRI and CT studies in 38 consecutive patients with pathologically proven craniopharyngiomas between January 2004 and February 2014 for the presence of calcification on CT scans, bright signal intensity on T1 weighted images, and cystic change on T2 weighted images. Results: Of the 38 craniopharyngiomas, 30 were adamantinomatous type and 8 were papillary type. On CT scans, calcification was present in 25 of 38 tumors. All calcified tumors were adamantinomatous type. Twenty four of 38 tumors had bright signal intensity on T1 weighted images. Of these 24 tumors, 22 (91.7%) were adamantinomatous and 2 were papillary type. Cystic change on T2 weighted images was noted in 37 of 38 tumors; only 1 tumor with papillary type did not show cystic change. Conclusion: T1 bright signal intensity and calcification on CT scans uniformly favor the adamantinomatous type over papillary type of craniopharyngioma in children. However, these findings are more variable in adults where calcification and T1 bright signal intensity occur in 70.6% and 58.8% respectively of adult adamantinomatous types of craniopharyngiomas.

Original languageEnglish (US)
Pages (from-to)466-470
Number of pages5
JournalJournal of Korean Neurosurgical Society
Volume59
Issue number5
DOIs
StatePublished - Sep 1 2016

Fingerprint

Craniopharyngioma
Neoplasms
Morbidity
Recurrence
Mortality

Keywords

  • Craniopharyngioma
  • Magnetic resonance imaging
  • Tomography scanners
  • X-ray computed

ASJC Scopus subject areas

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Craniopharyngiomas : Radiological differentiation of two types. / Lee, In Ho; Zan, Elcin; Bell, W. Robert; Burger, Peter C.; Sung, Heejong; Yousem, David Mark.

In: Journal of Korean Neurosurgical Society, Vol. 59, No. 5, 01.09.2016, p. 466-470.

Research output: Contribution to journalArticle

Lee, In Ho ; Zan, Elcin ; Bell, W. Robert ; Burger, Peter C. ; Sung, Heejong ; Yousem, David Mark. / Craniopharyngiomas : Radiological differentiation of two types. In: Journal of Korean Neurosurgical Society. 2016 ; Vol. 59, No. 5. pp. 466-470.
@article{c7a78530ccb74b7bbabd7abbbd7fa012,
title = "Craniopharyngiomas: Radiological differentiation of two types",
abstract = "Objective: To determine imaging features that may separate adamantinomatous and papillary variants of craniopharyngiomas given that tumors with adamantinomatous signature features are associated with higher recurrence rates, morbidity, and mortality. We specifically reviewed calcification on CT, T1 bright signal intensity, and cystic change on T2 weighted images for differentiating these two types. Methods: We retrospectively reviewed the MRI and CT studies in 38 consecutive patients with pathologically proven craniopharyngiomas between January 2004 and February 2014 for the presence of calcification on CT scans, bright signal intensity on T1 weighted images, and cystic change on T2 weighted images. Results: Of the 38 craniopharyngiomas, 30 were adamantinomatous type and 8 were papillary type. On CT scans, calcification was present in 25 of 38 tumors. All calcified tumors were adamantinomatous type. Twenty four of 38 tumors had bright signal intensity on T1 weighted images. Of these 24 tumors, 22 (91.7{\%}) were adamantinomatous and 2 were papillary type. Cystic change on T2 weighted images was noted in 37 of 38 tumors; only 1 tumor with papillary type did not show cystic change. Conclusion: T1 bright signal intensity and calcification on CT scans uniformly favor the adamantinomatous type over papillary type of craniopharyngioma in children. However, these findings are more variable in adults where calcification and T1 bright signal intensity occur in 70.6{\%} and 58.8{\%} respectively of adult adamantinomatous types of craniopharyngiomas.",
keywords = "Craniopharyngioma, Magnetic resonance imaging, Tomography scanners, X-ray computed",
author = "Lee, {In Ho} and Elcin Zan and Bell, {W. Robert} and Burger, {Peter C.} and Heejong Sung and Yousem, {David Mark}",
year = "2016",
month = "9",
day = "1",
doi = "10.3340/jkns.2016.59.5.466",
language = "English (US)",
volume = "59",
pages = "466--470",
journal = "Journal of Korean Neurosurgical Society",
issn = "2005-3711",
publisher = "Daehan sin'gyeong oe'gwa haghoe",
number = "5",

}

TY - JOUR

T1 - Craniopharyngiomas

T2 - Radiological differentiation of two types

AU - Lee, In Ho

AU - Zan, Elcin

AU - Bell, W. Robert

AU - Burger, Peter C.

AU - Sung, Heejong

AU - Yousem, David Mark

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objective: To determine imaging features that may separate adamantinomatous and papillary variants of craniopharyngiomas given that tumors with adamantinomatous signature features are associated with higher recurrence rates, morbidity, and mortality. We specifically reviewed calcification on CT, T1 bright signal intensity, and cystic change on T2 weighted images for differentiating these two types. Methods: We retrospectively reviewed the MRI and CT studies in 38 consecutive patients with pathologically proven craniopharyngiomas between January 2004 and February 2014 for the presence of calcification on CT scans, bright signal intensity on T1 weighted images, and cystic change on T2 weighted images. Results: Of the 38 craniopharyngiomas, 30 were adamantinomatous type and 8 were papillary type. On CT scans, calcification was present in 25 of 38 tumors. All calcified tumors were adamantinomatous type. Twenty four of 38 tumors had bright signal intensity on T1 weighted images. Of these 24 tumors, 22 (91.7%) were adamantinomatous and 2 were papillary type. Cystic change on T2 weighted images was noted in 37 of 38 tumors; only 1 tumor with papillary type did not show cystic change. Conclusion: T1 bright signal intensity and calcification on CT scans uniformly favor the adamantinomatous type over papillary type of craniopharyngioma in children. However, these findings are more variable in adults where calcification and T1 bright signal intensity occur in 70.6% and 58.8% respectively of adult adamantinomatous types of craniopharyngiomas.

AB - Objective: To determine imaging features that may separate adamantinomatous and papillary variants of craniopharyngiomas given that tumors with adamantinomatous signature features are associated with higher recurrence rates, morbidity, and mortality. We specifically reviewed calcification on CT, T1 bright signal intensity, and cystic change on T2 weighted images for differentiating these two types. Methods: We retrospectively reviewed the MRI and CT studies in 38 consecutive patients with pathologically proven craniopharyngiomas between January 2004 and February 2014 for the presence of calcification on CT scans, bright signal intensity on T1 weighted images, and cystic change on T2 weighted images. Results: Of the 38 craniopharyngiomas, 30 were adamantinomatous type and 8 were papillary type. On CT scans, calcification was present in 25 of 38 tumors. All calcified tumors were adamantinomatous type. Twenty four of 38 tumors had bright signal intensity on T1 weighted images. Of these 24 tumors, 22 (91.7%) were adamantinomatous and 2 were papillary type. Cystic change on T2 weighted images was noted in 37 of 38 tumors; only 1 tumor with papillary type did not show cystic change. Conclusion: T1 bright signal intensity and calcification on CT scans uniformly favor the adamantinomatous type over papillary type of craniopharyngioma in children. However, these findings are more variable in adults where calcification and T1 bright signal intensity occur in 70.6% and 58.8% respectively of adult adamantinomatous types of craniopharyngiomas.

KW - Craniopharyngioma

KW - Magnetic resonance imaging

KW - Tomography scanners

KW - X-ray computed

UR - http://www.scopus.com/inward/record.url?scp=84989189612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989189612&partnerID=8YFLogxK

U2 - 10.3340/jkns.2016.59.5.466

DO - 10.3340/jkns.2016.59.5.466

M3 - Article

VL - 59

SP - 466

EP - 470

JO - Journal of Korean Neurosurgical Society

JF - Journal of Korean Neurosurgical Society

SN - 2005-3711

IS - 5

ER -