Craniofacial growth in apert syndrome as measured by finite-element scaling analysis

Joan T. Richtsmeier

Research output: Contribution to journalArticlepeer-review

Abstract

A new tool for the study of biological form change is applied in a comparison of craniofacial growth in normal children and those affected with Apert syndrome. Using finite-element scaling analysis, the magnitude of size change during postnatal growth in the Apert sample was determined to be generally less than normal, and the magnitude of shape change was generally greater than normal. No consistent, statistically significant, alteration from normal growth was defined in the Apert sample, however. There appears to be no consistent effect on general cell and tissue proliferation in Apert syndrome. Rather, specific subpopulations of cells and tissues may be affected differentially over time.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalCells Tissues Organs
Volume133
Issue number1
DOIs
StatePublished - 1988

Keywords

  • Apert syndrome
  • Craniofacial growth
  • Deformation
  • Finite-element scaling analysis
  • Shape change

ASJC Scopus subject areas

  • Anatomy
  • Histology

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