TY - JOUR
T1 - Craniofacial bone infarcts in sickle cell disease
T2 - Clinical and radiological manifestations
AU - Watanabe, Memi
AU - Saito, Naoko
AU - Nadgir, Rohini N.
AU - Liao, Joseph H.
AU - Flower, Elisa N.
AU - Steinberg, Martin H.
AU - Sakai, Osamu
PY - 2013
Y1 - 2013
N2 - OBJECTIVE: To investigate the clinicoradiological manifestations of craniofacial bone infarcts in patients with sickle cell disease (SCD). MATERIALS AND METHODS: After institutional review board approval, we identified 85 SCD patients who underwent head and neck magnetic resonance imaging (MRI) during a period of 5 years (January 1, 2004-December 31, 2008) and reviewed their clinical presentations and radiological findings. RESULTS: Of 40 subjects with headache or facial pain, 6 (5 males, 1 female; age range, 2-22 years; 5 Hb SS, 1 Hb SC) were diagnosed with acute bone infarct by MRI. Of these 6, 4 demonstrated infarcts in the mandible. Magnetic resonance images showed bone marrow edema, subperiosteal fluid collections with susceptibility effects suggesting associated hemorrhage, and heterogeneous enhancement. CONCLUSIONS: Acute craniofacial bone infarcts were found in 7% of SCD patients who underwent MRI and in 15% of SCD patients who presented with pain. The MRI showed characteristic imaging findings including marrow edema, subperiosteal hematoma, and heterogeneous enhancement.
AB - OBJECTIVE: To investigate the clinicoradiological manifestations of craniofacial bone infarcts in patients with sickle cell disease (SCD). MATERIALS AND METHODS: After institutional review board approval, we identified 85 SCD patients who underwent head and neck magnetic resonance imaging (MRI) during a period of 5 years (January 1, 2004-December 31, 2008) and reviewed their clinical presentations and radiological findings. RESULTS: Of 40 subjects with headache or facial pain, 6 (5 males, 1 female; age range, 2-22 years; 5 Hb SS, 1 Hb SC) were diagnosed with acute bone infarct by MRI. Of these 6, 4 demonstrated infarcts in the mandible. Magnetic resonance images showed bone marrow edema, subperiosteal fluid collections with susceptibility effects suggesting associated hemorrhage, and heterogeneous enhancement. CONCLUSIONS: Acute craniofacial bone infarcts were found in 7% of SCD patients who underwent MRI and in 15% of SCD patients who presented with pain. The MRI showed characteristic imaging findings including marrow edema, subperiosteal hematoma, and heterogeneous enhancement.
KW - MRI
KW - bone infarct
KW - craniofacial bone
KW - sickle cell disease
KW - subperiosteal hematoma
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U2 - 10.1097/RCT.0b013e3182752967
DO - 10.1097/RCT.0b013e3182752967
M3 - Article
C2 - 23321839
AN - SCOPUS:84872974595
SN - 0363-8715
VL - 37
SP - 91
EP - 97
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 1
ER -