Craniofacial Bone

Ben P. Hung, Pinar Yilgor Huri, Joshua P. Temple, Amir Dorafshar, Warren L. Grayson

Research output: Chapter in Book/Report/Conference proceedingChapter


Craniofacial bone loss caused by trauma, cancer resection, or congenital diseases significantly impacts patients' facial appearance. An estimated 20% of annual bone transplants in the United States occur in the craniofacial region. Tissue engineering approaches that combine cells, scaffolds, and stimulatory cues hold considerable potential for regenerating functional bone. Several modalities are suited to generating scaffolds with the complex anatomical geometries of the craniofacial bones. Of these, three-dimensional printing (3DP) is particularly attractive as it is capable of providing precise control over both the macroscopic and microscopic architecture of the scaffold. In this chapter, we review various 3DP methods and their application in craniofacial bone tissue engineering. In addition, we examine how these techniques may be combined with nanocomposites to mimic bone composition and structure, and deliver bioactive molecules for regeneration and reconstruction of craniofacial bone.

Original languageEnglish (US)
Title of host publication3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128006641
ISBN (Print)9780128005477
StatePublished - Jan 27 2015


  • 3D printing
  • Craniofacial bone
  • Nanocomposites

ASJC Scopus subject areas

  • Medicine(all)
  • Health Professions(all)


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