Cowden syndrome presenting with trichilemmomas

Elise Ng, Vitaly Terushkin, Shane A. Meehan, Roger Ho, Miriam Keltz Pomeranz

Research output: Contribution to journalArticle

Abstract

Cowden syndrome (CS) is a genetic cancer predisposition syndrome that is associated with germline mutations in the phosphate and tensin homologue deleted on chromosome ten (PTEN) tumor suppressor gene. It is characterized by the formation of benign and malignant tumors. Characteristic benign tumors include trichilemmommas, acral keratoses, mucocutaneous neuromas, and oral papillomas. The most common malignant condition include breast, thyroid, and endometrial cancers. We present a case of a 30-year-old woman with CS, who initially presented with trichilemmomas that were misdiagnosed as comedonal acne. Recognition of the presenting features of CS is important to ensure proper referral, management, and treatment for these patients.

Original languageEnglish (US)
Pages (from-to)33-35
Number of pages3
JournalDermatology Online Journal
Volume22
Issue number12
StatePublished - Jan 1 2016
Externally publishedYes

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Multiple Hamartoma Syndrome
Keratosis
Neuroma
Neoplasms
Germ-Line Mutation
Acne Vulgaris
Papilloma
Genetic Predisposition to Disease
Endometrial Neoplasms
Diagnostic Errors
Tumor Suppressor Genes
Thyroid Neoplasms
Referral and Consultation
Extremities
Chromosomes
Phosphates
Breast Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Ng, E., Terushkin, V., Meehan, S. A., Ho, R., & Pomeranz, M. K. (2016). Cowden syndrome presenting with trichilemmomas. Dermatology Online Journal, 22(12), 33-35.

Cowden syndrome presenting with trichilemmomas. / Ng, Elise; Terushkin, Vitaly; Meehan, Shane A.; Ho, Roger; Pomeranz, Miriam Keltz.

In: Dermatology Online Journal, Vol. 22, No. 12, 01.01.2016, p. 33-35.

Research output: Contribution to journalArticle

Ng, E, Terushkin, V, Meehan, SA, Ho, R & Pomeranz, MK 2016, 'Cowden syndrome presenting with trichilemmomas', Dermatology Online Journal, vol. 22, no. 12, pp. 33-35.
Ng E, Terushkin V, Meehan SA, Ho R, Pomeranz MK. Cowden syndrome presenting with trichilemmomas. Dermatology Online Journal. 2016 Jan 1;22(12):33-35.
Ng, Elise ; Terushkin, Vitaly ; Meehan, Shane A. ; Ho, Roger ; Pomeranz, Miriam Keltz. / Cowden syndrome presenting with trichilemmomas. In: Dermatology Online Journal. 2016 ; Vol. 22, No. 12. pp. 33-35.
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