TY - JOUR
T1 - Cowden syndrome presenting with trichilemmomas
AU - Ng, Elise
AU - Terushkin, Vitaly
AU - Meehan, Shane A.
AU - Ho, Roger
AU - Pomeranz, Miriam Keltz
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Cowden syndrome (CS) is a genetic cancer predisposition syndrome that is associated with germline mutations in the phosphate and tensin homologue deleted on chromosome ten (PTEN) tumor suppressor gene. It is characterized by the formation of benign and malignant tumors. Characteristic benign tumors include trichilemmommas, acral keratoses, mucocutaneous neuromas, and oral papillomas. The most common malignant condition include breast, thyroid, and endometrial cancers. We present a case of a 30-year-old woman with CS, who initially presented with trichilemmomas that were misdiagnosed as comedonal acne. Recognition of the presenting features of CS is important to ensure proper referral, management, and treatment for these patients.
AB - Cowden syndrome (CS) is a genetic cancer predisposition syndrome that is associated with germline mutations in the phosphate and tensin homologue deleted on chromosome ten (PTEN) tumor suppressor gene. It is characterized by the formation of benign and malignant tumors. Characteristic benign tumors include trichilemmommas, acral keratoses, mucocutaneous neuromas, and oral papillomas. The most common malignant condition include breast, thyroid, and endometrial cancers. We present a case of a 30-year-old woman with CS, who initially presented with trichilemmomas that were misdiagnosed as comedonal acne. Recognition of the presenting features of CS is important to ensure proper referral, management, and treatment for these patients.
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M3 - Article
C2 - 28329541
AN - SCOPUS:85006857231
SN - 1087-2108
VL - 22
SP - 33
EP - 35
JO - Dermatology Online Journal
JF - Dermatology Online Journal
IS - 12
ER -