Courting a cure for Fragile X

Gul Dolen, Mark F. Bear

Research output: Contribution to journalArticle

Abstract

Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.

Original languageEnglish (US)
Pages (from-to)642-644
Number of pages3
JournalNeuron
Volume45
Issue number5
DOIs
StatePublished - Mar 3 2005

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Fragile X Syndrome
Mushroom Bodies
Courtship
Metabotropic Glutamate Receptors
Short-Term Memory
Intellectual Disability
Drosophila

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Courting a cure for Fragile X. / Dolen, Gul; Bear, Mark F.

In: Neuron, Vol. 45, No. 5, 03.03.2005, p. 642-644.

Research output: Contribution to journalArticle

Dolen, Gul ; Bear, Mark F. / Courting a cure for Fragile X. In: Neuron. 2005 ; Vol. 45, No. 5. pp. 642-644.
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