Courting a cure for Fragile X

Gül Dölen, Mark F. Bear

Research output: Contribution to journalShort surveypeer-review

Abstract

Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.

Original languageEnglish (US)
Pages (from-to)642-644
Number of pages3
JournalNeuron
Volume45
Issue number5
DOIs
StatePublished - Mar 3 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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