TY - JOUR
T1 - Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy
T2 - 1. Retinitis progression
AU - Jabs, Douglas A.
AU - Van Natta, Mark L.
AU - Thorne, Jennifer E.
AU - Weinberg, David V.
AU - Meredith, Travis A.
AU - Kuppermann, Baruch D.
AU - Sepkowitz, Kent
AU - Li, Helen K.
N1 - Funding Information:
Supported by cooperative agreements from the National Eye Institute, Bethesda, Maryland, to The Johns Hopkins University School of Medicine, Baltimore, Maryland (grant no.: U10 EY08052); The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (grant no.: U10 EY08057); and the University of Wisconsin, Madison, Wisconsin (grant no.: U10 EY08067). Additional support was provided by the National Center for Research Resources, Bethesda, Maryland (General Clinical Research Center grant nos.: 5MO1 RR00188 [Baylor College of Medicine, Houston, Texas], MO1 RR00052 [The Johns Hopkins University School of Medicine, Baltimore, Maryland], 5MO1 RR05096 [Louisiana State University, Baton Rouge, Louisiana], 5MO1 RR00865 [University of California, Los Angeles, California], 5MO1 RR05280 [University of Miami, Miami, Florida], 5M01 RR00046 [University of North Carolina, Chapel Hill, North Carolina], 5MO1 RR00043 [University of Southern California, Los Angeles, California], and 5MO1 RR00047 [Weill Medical College of Cornell University, New York, New York]).
PY - 2004/12
Y1 - 2004/12
N2 - To describe the course of cytomegalovirus (CMV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART). Multicenter, prospective, observational study. Two hundred seventy-one patients with AIDS and CMV retinitis. Follow-up every 3 months with medical history, ophthalmologic examination, laboratory testing, and fundus photographs. Photographs were evaluated for relapse of the retinitis (progression) by graders at a centralized reading center. Retinitis progression (movement of the border of a CMV lesion <750 μm over a <750-μm front or occurrence of a new lesion one-quarter disc area or more in size). The overall rate of retinitis progression was 0.10/person-year (PY); among those with CD4+ T-cell counts of <50/μl, it was 0.58/PY, compared to 0.02/PY among those with CD4+ T-cell counts of <200/μl (P<0.0001). In the multivariate analysis, significant risk factors for retinitis progression included a low CD4+ T-cell count, positive CMV load, longer time from AIDS diagnosis, and low Karnofsky score. Compared with the rate of retinitis progression (∼3.0/PY) reported in the pre-HAART era, the rate of retinitis progression was reduced among patients in the HAART era, even among those with low CD4+ T-cell counts, who might be expected to behave most like patients from the pre-HAART era. However, these events also occurred among patients with high CD4+ T-cell counts and presumed immune recovery. Continued ophthalmologic follow-up of patients with immune recovery is recommended to detect early retinitis progression. This article contains additional online-only material available at http://www.ophsource.com/ periodicals/ophtha.
AB - To describe the course of cytomegalovirus (CMV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART). Multicenter, prospective, observational study. Two hundred seventy-one patients with AIDS and CMV retinitis. Follow-up every 3 months with medical history, ophthalmologic examination, laboratory testing, and fundus photographs. Photographs were evaluated for relapse of the retinitis (progression) by graders at a centralized reading center. Retinitis progression (movement of the border of a CMV lesion <750 μm over a <750-μm front or occurrence of a new lesion one-quarter disc area or more in size). The overall rate of retinitis progression was 0.10/person-year (PY); among those with CD4+ T-cell counts of <50/μl, it was 0.58/PY, compared to 0.02/PY among those with CD4+ T-cell counts of <200/μl (P<0.0001). In the multivariate analysis, significant risk factors for retinitis progression included a low CD4+ T-cell count, positive CMV load, longer time from AIDS diagnosis, and low Karnofsky score. Compared with the rate of retinitis progression (∼3.0/PY) reported in the pre-HAART era, the rate of retinitis progression was reduced among patients in the HAART era, even among those with low CD4+ T-cell counts, who might be expected to behave most like patients from the pre-HAART era. However, these events also occurred among patients with high CD4+ T-cell counts and presumed immune recovery. Continued ophthalmologic follow-up of patients with immune recovery is recommended to detect early retinitis progression. This article contains additional online-only material available at http://www.ophsource.com/ periodicals/ophtha.
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U2 - 10.1016/j.ophtha.2004.05.031
DO - 10.1016/j.ophtha.2004.05.031
M3 - Article
C2 - 15582078
AN - SCOPUS:9644295997
SN - 0161-6420
VL - 111
SP - 2224-2231.e3
JO - Ophthalmology
JF - Ophthalmology
IS - 12
ER -