Coupling efficiency of brain β-adrenergic receptors to G(s) protein in suicide, alcoholism and control subjects

George N M Gurguis, Jukka Turkka, Marc Laruelle, Joel Kleinman, Markku Linnoila

Research output: Contribution to journalArticle

Abstract

Abnormal β-adrenergic receptor (βAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies βAR-mediated signal transduction. Moreover abnormal βAR function has been implicated in alcoholism. βAR antagonists, which were used as ligands in previous βAR binding studies, also bind to 5HT(1B/1Dβ) receptors; hence, their estimates of βAR density are confounded by binding to 5-HT(1B/1Dβ) receptors. More importantly, previous studies did not examine βAR agonist affinity or coupling efficiency to G(s) protein. We investigated agonist affinity and coupling efficiency of βAR to G(s) protein in the brains of ten suicide victims, six subjects with alcoholism, and eight controls. There were no differences in βAR density in either the frontal cortex or hippocampus of suicide victims or alcoholic subjects compared to controls. Preliminary results indicate βAR supercoupling in suicide victims in both brain regions and uncoupling in alcoholic subjects in the frontal cortex. These results are discussed in view of the existing literature on the role of βAR in suicide and alcoholism and the mechanism of action of antidepressants.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalPsychopharmacology
Volume145
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Adrenergic Receptors
Suicide
Alcoholism
Brain
Proteins
Frontal Lobe
Alcoholics
Receptor, Serotonin, 5-HT1D
Receptor, Serotonin, 5-HT1B
Adrenergic Agonists
Adrenergic Antagonists
Antidepressive Agents
Signal Transduction
Hippocampus
Ethanol
Ligands

Keywords

  • β-Adrenergic receptor
  • Alcoholism
  • Brain
  • Coupling
  • G(s) protein
  • Suicide

ASJC Scopus subject areas

  • Pharmacology

Cite this

Coupling efficiency of brain β-adrenergic receptors to G(s) protein in suicide, alcoholism and control subjects. / Gurguis, George N M; Turkka, Jukka; Laruelle, Marc; Kleinman, Joel; Linnoila, Markku.

In: Psychopharmacology, Vol. 145, No. 1, 1999, p. 31-38.

Research output: Contribution to journalArticle

Gurguis, George N M ; Turkka, Jukka ; Laruelle, Marc ; Kleinman, Joel ; Linnoila, Markku. / Coupling efficiency of brain β-adrenergic receptors to G(s) protein in suicide, alcoholism and control subjects. In: Psychopharmacology. 1999 ; Vol. 145, No. 1. pp. 31-38.
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