Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS)

Carol H. Christensen, Elizabeth A Platz, Gabriella Andreotti, Aaron Blair, Jane A. Hoppin, Stella Koutros, Charles F. Lynch, Dale P. Sandler, Michael C R Alavanja

Research output: Contribution to journalArticle

Abstract

Background: Coumaphos is an organophosphate livestock insecticide. Previous research in the Agricultural Health Study (AHS) cohort observed a positive association between coumaphos and prostate cancer in men with a family history of prostate cancer. Objectives: This study was performed to determine the association between coumaphos and other major cancer sites and to explore the consistency of the association with prostate cancer early (1993-1999) and later (2000-2005) in AHS follow-up. Methods: This study included 47,822 male licensed pesticide applicators. Incident cases were ascertained by linkage to state cancer registries, and exposure data were collected by enrollment questionnaire. Poisson regression was used to estimate rate ratio (RR) and 95% confidence interval (CI) of cancer for coumaphos exposure controlling for potentially confounding variables. Results: Approximately 8% of applicators reported use of coumaphos; 8.5% reported a family history of prostate cancer. Cumulative exposure to coumaphos was not associated with cancer risk overall or with any major cancer site including prostate. In men with a family history of prostate cancer, we observed a positive association between ever use of coumaphos and prostate cancer in both early (RR = 2.07; 95% CI, 1.19-3.62, p-interaction = 0.005) and later (RR = 1.46; 95% CI, 0.89-2.40; p-interaction = 0.11) periods of follow-up. Across all years, this association was statistically significant (RR = 1.65; 95% CI, 1.13-2.38; p-interaction = 0.004). Conclusion: Coumaphos was not associated with any cancer evaluated here. In men with a family history of disease, there was evidence of an association between coumaphos and prostate cancer, possibly due to genetic susceptibility; however, other explanations, including chance, are plausible.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalEnvironmental Health Perspectives
Volume118
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Coumaphos
Prostatic Neoplasms
Health
Neoplasms
Confidence Intervals
Confounding Factors (Epidemiology)
Organophosphates
Livestock
Genetic Predisposition to Disease
Insecticides
Pesticides
Registries
Prostate
Cohort Studies

Keywords

  • Agriculture
  • Cancer
  • Coumaphos
  • Insecticide
  • Livestock
  • Neoplasms
  • Occupational exposure
  • Organophosphate
  • Pesticide
  • Prostate

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Christensen, C. H., Platz, E. A., Andreotti, G., Blair, A., Hoppin, J. A., Koutros, S., ... Alavanja, M. C. R. (2010). Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS). Environmental Health Perspectives, 118(1), 92-96. https://doi.org/10.1289/ehp.0800446

Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS). / Christensen, Carol H.; Platz, Elizabeth A; Andreotti, Gabriella; Blair, Aaron; Hoppin, Jane A.; Koutros, Stella; Lynch, Charles F.; Sandler, Dale P.; Alavanja, Michael C R.

In: Environmental Health Perspectives, Vol. 118, No. 1, 01.2010, p. 92-96.

Research output: Contribution to journalArticle

Christensen, CH, Platz, EA, Andreotti, G, Blair, A, Hoppin, JA, Koutros, S, Lynch, CF, Sandler, DP & Alavanja, MCR 2010, 'Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS)', Environmental Health Perspectives, vol. 118, no. 1, pp. 92-96. https://doi.org/10.1289/ehp.0800446
Christensen, Carol H. ; Platz, Elizabeth A ; Andreotti, Gabriella ; Blair, Aaron ; Hoppin, Jane A. ; Koutros, Stella ; Lynch, Charles F. ; Sandler, Dale P. ; Alavanja, Michael C R. / Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS). In: Environmental Health Perspectives. 2010 ; Vol. 118, No. 1. pp. 92-96.
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abstract = "Background: Coumaphos is an organophosphate livestock insecticide. Previous research in the Agricultural Health Study (AHS) cohort observed a positive association between coumaphos and prostate cancer in men with a family history of prostate cancer. Objectives: This study was performed to determine the association between coumaphos and other major cancer sites and to explore the consistency of the association with prostate cancer early (1993-1999) and later (2000-2005) in AHS follow-up. Methods: This study included 47,822 male licensed pesticide applicators. Incident cases were ascertained by linkage to state cancer registries, and exposure data were collected by enrollment questionnaire. Poisson regression was used to estimate rate ratio (RR) and 95{\%} confidence interval (CI) of cancer for coumaphos exposure controlling for potentially confounding variables. Results: Approximately 8{\%} of applicators reported use of coumaphos; 8.5{\%} reported a family history of prostate cancer. Cumulative exposure to coumaphos was not associated with cancer risk overall or with any major cancer site including prostate. In men with a family history of prostate cancer, we observed a positive association between ever use of coumaphos and prostate cancer in both early (RR = 2.07; 95{\%} CI, 1.19-3.62, p-interaction = 0.005) and later (RR = 1.46; 95{\%} CI, 0.89-2.40; p-interaction = 0.11) periods of follow-up. Across all years, this association was statistically significant (RR = 1.65; 95{\%} CI, 1.13-2.38; p-interaction = 0.004). Conclusion: Coumaphos was not associated with any cancer evaluated here. In men with a family history of disease, there was evidence of an association between coumaphos and prostate cancer, possibly due to genetic susceptibility; however, other explanations, including chance, are plausible.",
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N2 - Background: Coumaphos is an organophosphate livestock insecticide. Previous research in the Agricultural Health Study (AHS) cohort observed a positive association between coumaphos and prostate cancer in men with a family history of prostate cancer. Objectives: This study was performed to determine the association between coumaphos and other major cancer sites and to explore the consistency of the association with prostate cancer early (1993-1999) and later (2000-2005) in AHS follow-up. Methods: This study included 47,822 male licensed pesticide applicators. Incident cases were ascertained by linkage to state cancer registries, and exposure data were collected by enrollment questionnaire. Poisson regression was used to estimate rate ratio (RR) and 95% confidence interval (CI) of cancer for coumaphos exposure controlling for potentially confounding variables. Results: Approximately 8% of applicators reported use of coumaphos; 8.5% reported a family history of prostate cancer. Cumulative exposure to coumaphos was not associated with cancer risk overall or with any major cancer site including prostate. In men with a family history of prostate cancer, we observed a positive association between ever use of coumaphos and prostate cancer in both early (RR = 2.07; 95% CI, 1.19-3.62, p-interaction = 0.005) and later (RR = 1.46; 95% CI, 0.89-2.40; p-interaction = 0.11) periods of follow-up. Across all years, this association was statistically significant (RR = 1.65; 95% CI, 1.13-2.38; p-interaction = 0.004). Conclusion: Coumaphos was not associated with any cancer evaluated here. In men with a family history of disease, there was evidence of an association between coumaphos and prostate cancer, possibly due to genetic susceptibility; however, other explanations, including chance, are plausible.

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