Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?

Chi V. Dang, Feng Li, Linda A. Lee

Research output: Contribution to journalShort surveypeer-review

Abstract

MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc's transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability.

Original languageEnglish (US)
Pages (from-to)1465-1466
Number of pages2
JournalCell Cycle
Volume4
Issue number11
DOIs
StatePublished - Nov 2005

Keywords

  • Genomic instability
  • Reactive oxygen
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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