TY - CHAP
T1 - Cough sensors. V. Pharmacological modulation of cough sensors
AU - Mazzone, S. B.
AU - Undem, B. J.
PY - 2009
Y1 - 2009
N2 - Abstract Several airway afferent nerve subtypes have been implicated in coughing. These include bronchopulmonary C-fibers, rapidly adapting airway mechanorecep-tors and touch-sensitive tracheal Aδ-fibers (also called cough receptors). Although the last two afferent nerve subtypes are primarily sensitive to mechanical stimuli, all can be acted upon by one or more different chemical stimuli. In this review we catalogue the chemical agents that stimulate and/or modulate the activity of the airway afferent nerves involved in cough, and describe the specific mechanisms involved in these effects. In addition, we describe the mechanisms of action of a number of chemical inhibitors of these afferent nerve subtypes, and attempt to relate this information to the regulation of coughing in health and disease.
AB - Abstract Several airway afferent nerve subtypes have been implicated in coughing. These include bronchopulmonary C-fibers, rapidly adapting airway mechanorecep-tors and touch-sensitive tracheal Aδ-fibers (also called cough receptors). Although the last two afferent nerve subtypes are primarily sensitive to mechanical stimuli, all can be acted upon by one or more different chemical stimuli. In this review we catalogue the chemical agents that stimulate and/or modulate the activity of the airway afferent nerves involved in cough, and describe the specific mechanisms involved in these effects. In addition, we describe the mechanisms of action of a number of chemical inhibitors of these afferent nerve subtypes, and attempt to relate this information to the regulation of coughing in health and disease.
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U2 - 10.1007/978-3-540-79842-2_6
DO - 10.1007/978-3-540-79842-2_6
M3 - Chapter
C2 - 18825338
AN - SCOPUS:56049125283
SN - 9783540798415
T3 - Handbook of Experimental Pharmacology
SP - 99
EP - 127
BT - Pharmacology and Therapeutics of Cough
ER -