Cough sensors. V. Pharmacological modulation of cough sensors

S. B. Mazzone, B. J. Undem

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Abstract Several airway afferent nerve subtypes have been implicated in coughing. These include bronchopulmonary C-fibers, rapidly adapting airway mechanorecep-tors and touch-sensitive tracheal Aδ-fibers (also called cough receptors). Although the last two afferent nerve subtypes are primarily sensitive to mechanical stimuli, all can be acted upon by one or more different chemical stimuli. In this review we catalogue the chemical agents that stimulate and/or modulate the activity of the airway afferent nerves involved in cough, and describe the specific mechanisms involved in these effects. In addition, we describe the mechanisms of action of a number of chemical inhibitors of these afferent nerve subtypes, and attempt to relate this information to the regulation of coughing in health and disease.

Original languageEnglish (US)
Title of host publicationPharmacology and Therapeutics of Cough
Pages99-127
Number of pages29
DOIs
StatePublished - Jun 25 2009
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume187
ISSN (Print)0171-2004

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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