Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

M. Brozmanova, J. Plevkova, M. Tatar, M. Kollarik

Research output: Contribution to journalArticle

Abstract

Increased cough reflex sensitivity is found in patients with allergic rhinitis and may contribute to cough caused by rhinitis. We have reported that cough to citric acid is enhanced in the guinea pig model of allergic rhinitis. Here we address the hypothesis that the cough reflex sensitivity is increased in this model. The data from our previous studies were analyzed for the cough reflex sensitivity. The allergic inflammation in the nose was induced by repeated intranasal instillations of ovalbumin in the ovalbumin-sensitized guinea pigs. Cough was induced by inhalation of doubling concentrations of citric acid (0.05-1.6 M). Cough threshold was defined as the lowest concentration of citric acid causing two coughs (C2, expressed as geometric mean [95% confidence interval]). We found that the cough threshold was reduced in animals with allergic rhinitis. C2 was 0.5 M [0.36-0.71 M] and 0.15 M [0.1-0.23 M] prior and after repeated intranasal instillations of ovalbumin, respectively, P

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Physiology and Pharmacology
Volume59
Issue numberSUPPL. 6
StatePublished - Dec 2008

Fingerprint

Cough
Reflex
Guinea Pigs
Ovalbumin
Citric Acid
Allergic Rhinitis
Rhinitis
Nose
Inhalation
Confidence Intervals
Inflammation

Keywords

  • Allergic rhinitis
  • Chronic cough
  • Cough threshold

ASJC Scopus subject areas

  • Pharmacology
  • Physiology
  • Medicine(all)

Cite this

Brozmanova, M., Plevkova, J., Tatar, M., & Kollarik, M. (2008). Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. Journal of Physiology and Pharmacology, 59(SUPPL. 6), 153-161.

Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. / Brozmanova, M.; Plevkova, J.; Tatar, M.; Kollarik, M.

In: Journal of Physiology and Pharmacology, Vol. 59, No. SUPPL. 6, 12.2008, p. 153-161.

Research output: Contribution to journalArticle

Brozmanova, M, Plevkova, J, Tatar, M & Kollarik, M 2008, 'Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis', Journal of Physiology and Pharmacology, vol. 59, no. SUPPL. 6, pp. 153-161.
Brozmanova M, Plevkova J, Tatar M, Kollarik M. Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. Journal of Physiology and Pharmacology. 2008 Dec;59(SUPPL. 6):153-161.
Brozmanova, M. ; Plevkova, J. ; Tatar, M. ; Kollarik, M. / Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. In: Journal of Physiology and Pharmacology. 2008 ; Vol. 59, No. SUPPL. 6. pp. 153-161.
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