Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

M. Brozmanova, J. Plevkova, M. Tatar, M. Kollarik

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Abstract

Increased cough reflex sensitivity is found in patients with allergic rhinitis and may contribute to cough caused by rhinitis. We have reported that cough to citric acid is enhanced in the guinea pig model of allergic rhinitis. Here we address the hypothesis that the cough reflex sensitivity is increased in this model. The data from our previous studies were analyzed for the cough reflex sensitivity. The allergic inflammation in the nose was induced by repeated intranasal instillations of ovalbumin in the ovalbumin-sensitized guinea pigs. Cough was induced by inhalation of doubling concentrations of citric acid (0.05-1.6 M). Cough threshold was defined as the lowest concentration of citric acid causing two coughs (C2, expressed as geometric mean [95% confidence interval]). We found that the cough threshold was reduced in animals with allergic rhinitis. C2 was 0.5 M [0.36-0.71 M] and 0.15 M [0.1-0.23 M] prior and after repeated intranasal instillations of ovalbumin, respectively, P

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Physiology and Pharmacology
Volume59
Issue numberSUPPL. 6
StatePublished - Dec 2008

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Keywords

  • Allergic rhinitis
  • Chronic cough
  • Cough threshold

ASJC Scopus subject areas

  • Pharmacology
  • Physiology
  • Medicine(all)

Cite this

Brozmanova, M., Plevkova, J., Tatar, M., & Kollarik, M. (2008). Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. Journal of Physiology and Pharmacology, 59(SUPPL. 6), 153-161.