Costimulation, tolerance and ignorance of cytolytic T lymphocytes in immune responses to tumor antigens

Ignacio Melero, Nathan Bach, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Despite the fact that many tumors express MHC class I molecules presenting 'foreign' peptide antigens, a vigorous tumor-destructing immune response is seldom detected. A possible explanation is that tumors cannot provide adequate costimulatory signals as provided by professional antigen presenting cells. CD28, upon interacting with B7, triggers costimulatory signals critical for the T-cell response. Transfection of tumor cells with B7 augments the immunogenicity of the tumor so that an anti-tumor immune response can be amplified. When B7-CD28 costimulation is provided CTL specific for otherwise silent epitopes can be activated. Therefore, unresponsiveness oft cells to many tumor antigens should be considered as ignorance rather than tolerance. Immunological ignorance may thus contribute to the failure of the immune system to respond against the tumor antigens.

Original languageEnglish (US)
Pages (from-to)2035-2041
Number of pages7
JournalLife Sciences
Volume60
Issue number23
DOIs
StatePublished - May 2 1997
Externally publishedYes

Keywords

  • costimulation
  • T cells
  • tolerance
  • tumor antigens

ASJC Scopus subject areas

  • Pharmacology

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