TY - JOUR
T1 - Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors
AU - Li, Yiwen
AU - Hellström, Karl Erik
AU - Newby, Stephanie Ashe
AU - Chen, Lieping
PY - 1996/2/1
Y1 - 1996/2/1
N2 - Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit an efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.
AB - Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit an efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.
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U2 - 10.1084/jem.183.2.639
DO - 10.1084/jem.183.2.639
M3 - Article
C2 - 8627175
AN - SCOPUS:0030041637
SN - 0022-1007
VL - 183
SP - 639
EP - 644
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -