Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Yiwen Li, Karl Erik Hellström, Stephanie Ashe Newby, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit an efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalJournal of Experimental Medicine
Volume183
Issue number2
DOIs
StatePublished - Feb 1 1996
Externally publishedYes

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Immunity
Neoplasms
Sarcoma
Transfection
B7 Antigens
Ligands
Adoptive Immunotherapy
Cytotoxic T-Lymphocytes
Genes
Melanoma
Neoplasm Metastasis
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. / Li, Yiwen; Hellström, Karl Erik; Newby, Stephanie Ashe; Chen, Lieping.

In: Journal of Experimental Medicine, Vol. 183, No. 2, 01.02.1996, p. 639-644.

Research output: Contribution to journalArticle

Li, Yiwen ; Hellström, Karl Erik ; Newby, Stephanie Ashe ; Chen, Lieping. / Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. In: Journal of Experimental Medicine. 1996 ; Vol. 183, No. 2. pp. 639-644.
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