Cost utility of lateral-flow urine lipoarabinomannan for tuberculosis diagnosis in HIV-infected African adults

D. Sun, S. Dorman, M. Shah, Y. C. Manabe, V. M. Moodley, M. P. Nicol, D. W. Dowdy

Research output: Contribution to journalArticlepeer-review

Abstract

SETTING: In-patient hospitals in South Africa and Uganda. OBJECTIVE: To evaluate the cost-effectiveness of a lateral-flow urine lipoarabinomannan (LAM) test when added to existing strategies for tuberculosis (TB) diagnosis in human immunodeficiency virus infected adults (CD4+ T-cell counts < 100 cells/μl) with symptoms of active TB. DESIGN: Decision-analytic cost-utility model, with the primary outcome being the incremental cost-effectiveness ratio, expressed in 2010 US dollars per disability-adjusted life year (DALY) averted from the perspective of a public sector TB control program. RESULTS AND CONCLUSION: For every 1000 patients tested, adding lateral-flow urine LAM generated 80 incremental appropriate anti-tuberculosis treatments and averted 224 DALYs. Estimated cost utility was USS353 per DALY averted (95% uncertainty range S192-S1161) in South Africa and S86 per DALY averted (95% uncertainty range S49-S239) in Uganda, reflecting the lower treatment costs in Uganda. Cost utility was most sensitive to assay specificity, cost of anti-tuberculosis treatment, life expectancy after TB cure and cohort TB prevalence, but did not rise above S1500 per DALY averted in South Africa under any one-way sensitivity analysis. The probability of acceptability was >99.8% at a per- DALY willingness-to-pay threshold equal to the per capita gross domestic product in South Africa (S7275) and Uganda (S509).

Original languageEnglish (US)
Pages (from-to)552-558
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • Diagnostic tests and procedures
  • Economic
  • HIV
  • Models
  • South africa
  • Tuberculosis
  • Uganda

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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