Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal

Elena Losina, Hapsatou Touré, Lauren M. Uhler, Xavier Anglaret, A. David Paltiel, Eric Balestre, Rochelle P. Walensky, Eugène Messou, Milton C. Weinstein, François Dabis, Kenneth A. Freedberg, Melissa Bender, John Chiosi, Jennifer Chu, Sarah Chung, Andrea Ciaranello, Mariam O. Fofana, Heather E. Hsu, Zhigang Lu, Bethany MorrisBrandon Morris, Erin Rhode, Caroline Sloan, Callie A. Scott, Lauren Uhler, Kara Cotich, Sue J. Goldie, April D. Kimmel, Marc Lipsitch, Chara Rydzak, George R. Seage, Yazdan Yazdanpanah, Roger Salamon, Christine Danel, Thérèse N'Dri-Yoman, Raoul Moh, Eric Ouattara, Siaka Touré, Catherine Seyler, Nagalingeswaran Kumarasamy, A. K. Ganesh, Robin Wood, Glenda Gray, James McIntyre, Neil A. Martinson, Lerato Mohapi, Timothy Flanigan, Kenneth Mayer

Research output: Contribution to journalArticle

Abstract

Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa. Methods and Findings: We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) International model to project the clinical benefits and cost-effectiveness of LTFU-prevention programs from a payer perspective. These programs include components such as eliminating ART co-payments, eliminating charges to patients for opportunistic infection-related drugs, improving personnel training, and providing meals and reimbursing for transportation for participants. The efficacies and costs of these interventions were extensively varied in sensitivity analyses. We used World Health Organization criteria of

Original languageEnglish (US)
Article numbere1000173
JournalPLoS Medicine
Volume6
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Losina, E., Touré, H., Uhler, L. M., Anglaret, X., Paltiel, A. D., Balestre, E., Walensky, R. P., Messou, E., Weinstein, M. C., Dabis, F., Freedberg, K. A., Bender, M., Chiosi, J., Chu, J., Chung, S., Ciaranello, A., Fofana, M. O., Hsu, H. E., Lu, Z., ... Mayer, K. (2009). Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal. PLoS Medicine, 6(10), [e1000173]. https://doi.org/10.1371/journal.pmed.1000173