Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal

Elena Losina; Hapsatou Touré; Lauren M. Uhler; Xavier Anglaret; A. David Paltiel; Eric Balestre; Rochelle P. Walensky; Eugène Messou; Milton C. Weinstein; François Dabis; Kenneth A. Freedberg; Melissa Bender; John Chiosi; Jennifer Chu; Sarah Chung; Andrea Ciaranello; Mariam O. Fofana; Heather E. Hsu; Zhigang Lu; Bethany Morris; Brandon Morris; Erin Rhode; Caroline Sloan; Callie A. Scott; Lauren Uhler; Kara Cotich; Sue J. Goldie; April D. Kimmel; Marc Lipsitch; Chara Rydzak; George R. Seage; Yazdan Yazdanpanah; Roger Salamon; Christine Danel; Thérèse N'Dri-Yoman; Raoul Moh; Eric Ouattara; Siaka Touré; Catherine Seyler; Nagalingeswaran Kumarasamy; A. K. Ganesh; Robin Wood; Glenda Gray; James McIntyre; Neil A. Martinson; Lerato Mohapi; Timothy Flanigan; Kenneth Mayer

doi:10.1371/journal.pmed.1000173

Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal

Elena Losina, Hapsatou Touré, Lauren M. Uhler, Xavier Anglaret, A. David Paltiel, Eric Balestre, Rochelle P. Walensky, Eugène Messou, Milton C. Weinstein, François Dabis, Kenneth A. Freedberg, Melissa Bender, John Chiosi, Jennifer Chu, Sarah Chung, Andrea Ciaranello, Mariam O. Fofana, Heather E. Hsu, Zhigang Lu, Bethany MorrisBrandon Morris, Erin Rhode, Caroline Sloan, Callie A. Scott, Lauren Uhler, Kara Cotich, Sue J. Goldie, April D. Kimmel, Marc Lipsitch, Chara Rydzak, George R. Seage, Yazdan Yazdanpanah, Roger Salamon, Christine Danel, Thérèse N'Dri-Yoman, Raoul Moh, Eric Ouattara, Siaka Touré, Catherine Seyler, Nagalingeswaran Kumarasamy, A. K. Ganesh, Robin Wood, Glenda Gray, James McIntyre, Neil A. Martinson, Lerato Mohapi, Timothy Flanigan, Kenneth Mayer

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa. Methods and Findings: We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) International model to project the clinical benefits and cost-effectiveness of LTFU-prevention programs from a payer perspective. These programs include components such as eliminating ART co-payments, eliminating charges to patients for opportunistic infection-related drugs, improving personnel training, and providing meals and reimbursing for transportation for participants. The efficacies and costs of these interventions were extensively varied in sensitivity analyses. We used World Health Organization criteria of

Original language	English (US)
Article number	e1000173
Journal	PLoS Medicine
Volume	6
Issue number	10
DOIs	https://doi.org/10.1371/journal.pmed.1000173
State	Published - Oct 2009
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1371/journal.pmed.1000173

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Losina, E., Touré, H., Uhler, L. M., Anglaret, X., Paltiel, A. D., Balestre, E., Walensky, R. P., Messou, E., Weinstein, M. C., Dabis, F., Freedberg, K. A., Bender, M., Chiosi, J., Chu, J., Chung, S., Ciaranello, A., Fofana, M. O., Hsu, H. E., Lu, Z., ... Mayer, K. (2009). Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal. PLoS Medicine, 6(10), Article e1000173. https://doi.org/10.1371/journal.pmed.1000173

Losina, E, Touré, H, Uhler, LM, Anglaret, X, Paltiel, AD, Balestre, E, Walensky, RP, Messou, E, Weinstein, MC, Dabis, F, Freedberg, KA, Bender, M, Chiosi, J, Chu, J, Chung, S, Ciaranello, A, Fofana, MO, Hsu, HE, Lu, Z, Morris, B, Morris, B, Rhode, E, Sloan, C, Scott, CA, Uhler, L, Cotich, K, Goldie, SJ, Kimmel, AD, Lipsitch, M, Rydzak, C, Seage, GR, Yazdanpanah, Y, Salamon, R, Danel, C, N'Dri-Yoman, T, Moh, R, Ouattara, E, Touré, S, Seyler, C, Kumarasamy, N, Ganesh, AK, Wood, R, Gray, G, McIntyre, J, Martinson, NA, Mohapi, L, Flanigan, T & Mayer, K 2009, 'Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal', PLoS Medicine, vol. 6, no. 10, e1000173. https://doi.org/10.1371/journal.pmed.1000173

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title = "Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A C{\^o}te d'Ivoire appraisal",

abstract = "Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa. Methods and Findings: We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) International model to project the clinical benefits and cost-effectiveness of LTFU-prevention programs from a payer perspective. These programs include components such as eliminating ART co-payments, eliminating charges to patients for opportunistic infection-related drugs, improving personnel training, and providing meals and reimbursing for transportation for participants. The efficacies and costs of these interventions were extensively varied in sensitivity analyses. We used World Health Organization criteria of ",

author = "Elena Losina and Hapsatou Tour{\'e} and Uhler, {Lauren M.} and Xavier Anglaret and Paltiel, {A. David} and Eric Balestre and Walensky, {Rochelle P.} and Eug{\`e}ne Messou and Weinstein, {Milton C.} and Fran{\c c}ois Dabis and Freedberg, {Kenneth A.} and Melissa Bender and John Chiosi and Jennifer Chu and Sarah Chung and Andrea Ciaranello and Fofana, {Mariam O.} and Hsu, {Heather E.} and Zhigang Lu and Bethany Morris and Brandon Morris and Erin Rhode and Caroline Sloan and Scott, {Callie A.} and Lauren Uhler and Kara Cotich and Goldie, {Sue J.} and Kimmel, {April D.} and Marc Lipsitch and Chara Rydzak and Seage, {George R.} and Yazdan Yazdanpanah and Roger Salamon and Christine Danel and Th{\'e}r{\`e}se N'Dri-Yoman and Raoul Moh and Eric Ouattara and Siaka Tour{\'e} and Catherine Seyler and Nagalingeswaran Kumarasamy and Ganesh, {A. K.} and Robin Wood and Glenda Gray and James McIntyre and Martinson, {Neil A.} and Lerato Mohapi and Timothy Flanigan and Kenneth Mayer",

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T1 - Cost-effectiveness of preventing loss to follow-up in HIV treatment programs

T2 - A Côte d'Ivoire appraisal

AU - Losina, Elena

AU - Touré, Hapsatou

AU - Uhler, Lauren M.

AU - Anglaret, Xavier

AU - Paltiel, A. David

AU - Balestre, Eric

AU - Walensky, Rochelle P.

AU - Messou, Eugène

AU - Weinstein, Milton C.

AU - Dabis, François

AU - Freedberg, Kenneth A.

AU - Bender, Melissa

AU - Chiosi, John

AU - Chu, Jennifer

AU - Chung, Sarah

AU - Ciaranello, Andrea

AU - Fofana, Mariam O.

AU - Hsu, Heather E.

AU - Lu, Zhigang

AU - Morris, Bethany

AU - Morris, Brandon

AU - Rhode, Erin

AU - Sloan, Caroline

AU - Scott, Callie A.

AU - Uhler, Lauren

AU - Cotich, Kara

AU - Goldie, Sue J.

AU - Kimmel, April D.

AU - Lipsitch, Marc

AU - Rydzak, Chara

AU - Seage, George R.

AU - Yazdanpanah, Yazdan

AU - Salamon, Roger

AU - Danel, Christine

AU - N'Dri-Yoman, Thérèse

AU - Moh, Raoul

AU - Ouattara, Eric

AU - Touré, Siaka

AU - Seyler, Catherine

AU - Kumarasamy, Nagalingeswaran

AU - Ganesh, A. K.

AU - Wood, Robin

AU - Gray, Glenda

AU - McIntyre, James

AU - Martinson, Neil A.

AU - Mohapi, Lerato

AU - Flanigan, Timothy

AU - Mayer, Kenneth

PY - 2009/10

Y1 - 2009/10

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Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: A Côte d'Ivoire appraisal

Abstract

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