Cost-effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds

Kenneth J. Smith; Bruce Y. Lee; Mary Patricia Nowalk; Mahlon Raymund; Richard K. Zimmerman

doi:10.1016/j.vaccine.2010.09.053

Cost-effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds

Kenneth J. Smith, Bruce Y. Lee, Mary Patricia Nowalk, Mahlon Raymund, Richard K. Zimmerman

Research output: Contribution to journal › Article

Abstract

Influenza vaccination is now recommended for all ages; CDC pneumococcal polysaccharide vaccination (PPV) recommendations are comorbidity-based in nonelderly patients. We constructed a Markov model to estimate the cost-effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds. Patients were followed for 10 years, with differing time horizons examined in sensitivity analyses. With 100% vaccine uptake, dual vaccination cost $37,700/QALY gained compared to a CDC recommendation strategy; with observed vaccine uptake, dual vaccination cost $5,300/QALY. Results were sensitive to shorter time horizons, favoring CDC recommendations. We found dual vaccination of all 50-year-olds economically reasonable. Shorter duration models may not fully account for PPV effectiveness.

Original language	English (US)
Pages (from-to)	7620-7625
Number of pages	6
Journal	Vaccine
Volume	28
Issue number	48
DOIs	https://doi.org/10.1016/j.vaccine.2010.09.053
State	Published - Nov 10 2010
Externally published	Yes

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Keywords

Cost-effectiveness
Influenza vaccine
Pneumococcal polysaccharide vaccine
Secondary pneumococcal pneumonia

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

Cite this

Smith, K. J., Lee, B. Y., Nowalk, M. P., Raymund, M., & Zimmerman, R. K. (2010). Cost-effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds. Vaccine, 28(48), 7620-7625. https://doi.org/10.1016/j.vaccine.2010.09.053

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Access to Document

10.1016/j.vaccine.2010.09.053