Cost-effective analysis of genotyping using oral cells in the geriatric population.

T. Juárez-Cedillo, S. Sánchez-García, J. F. Mould-Quevedo, C. García-Peña, Joseph J Gallo, F. A. Wagner, G. Vargas-Alarcón

Research output: Contribution to journalArticle

Abstract

We evaluated the cost-effectiveness of using buccal swab brushes in comparison with blood samples for obtaining DNA for large epidemiological studies of the elderly population. The data reported here are from the third phase of the Integral Study of Depression among the Elderly in Mexico City's Mexican Institute of Social Security, conducted in 2007. The total cost of the two procedures was determined. The measurement of effectiveness was the quality and quantity of DNA measured in ng/μL and the use of this DNA for the determination of apolipoprotein E (APO E) polymorphism by PCR. Similar rates of amplification were obtained with the two techniques. The cost of the buccal swab brushes, including sample collection and DNA extraction, was US$16.63, compared to the cost per blood sample of US$23.35. Using the buccal swab, the savings was US$6.72 per patient (P <0.05). The effectiveness was similar. Quantity and quality of DNA obtained were similar for the oral and blood procedures, demonstrating that the swab brush technique offers a feasible alternative for large-scale epidemiological studies.

Original languageEnglish (US)
Pages (from-to)1886-1895
Number of pages10
JournalGenetics and Molecular Research
Volume9
Issue number3
StatePublished - 2010
Externally publishedYes

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Geriatrics
Cheek
Costs and Cost Analysis
DNA
Population
Epidemiologic Studies
Social Security
Apolipoproteins E
Mexico
Cost-Benefit Analysis
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Juárez-Cedillo, T., Sánchez-García, S., Mould-Quevedo, J. F., García-Peña, C., Gallo, J. J., Wagner, F. A., & Vargas-Alarcón, G. (2010). Cost-effective analysis of genotyping using oral cells in the geriatric population. Genetics and Molecular Research, 9(3), 1886-1895.

Cost-effective analysis of genotyping using oral cells in the geriatric population. / Juárez-Cedillo, T.; Sánchez-García, S.; Mould-Quevedo, J. F.; García-Peña, C.; Gallo, Joseph J; Wagner, F. A.; Vargas-Alarcón, G.

In: Genetics and Molecular Research, Vol. 9, No. 3, 2010, p. 1886-1895.

Research output: Contribution to journalArticle

Juárez-Cedillo, T, Sánchez-García, S, Mould-Quevedo, JF, García-Peña, C, Gallo, JJ, Wagner, FA & Vargas-Alarcón, G 2010, 'Cost-effective analysis of genotyping using oral cells in the geriatric population.', Genetics and Molecular Research, vol. 9, no. 3, pp. 1886-1895.
Juárez-Cedillo T, Sánchez-García S, Mould-Quevedo JF, García-Peña C, Gallo JJ, Wagner FA et al. Cost-effective analysis of genotyping using oral cells in the geriatric population. Genetics and Molecular Research. 2010;9(3):1886-1895.
Juárez-Cedillo, T. ; Sánchez-García, S. ; Mould-Quevedo, J. F. ; García-Peña, C. ; Gallo, Joseph J ; Wagner, F. A. ; Vargas-Alarcón, G. / Cost-effective analysis of genotyping using oral cells in the geriatric population. In: Genetics and Molecular Research. 2010 ; Vol. 9, No. 3. pp. 1886-1895.
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