COSMIC (Cohort Studies of Memory in an International Consortium)

An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

Perminder S. Sachdev, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Kenneth Rockwood, Shifu Xiao, Juan Li, Xia Li, Carol Brayne, Fiona E. Matthews, Blossom C M Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie Laure Ancelin, Sudha Seshadri, Rhoda Au, Alexa S. Beiser, Linda C W Lam & 25 others Candy H Y Wong, Ada W T Fung, Ki W. Kim, Ji W. Han, Tae H. Kim, Ronald C. Petersen, Rosebud O. Roberts, Michelle M. Mielke, Mary Ganguli, Hiroko H. Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze P. Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Kenichi Meguro, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara

Research output: Contribution to journalArticle

Abstract

Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.

Original languageEnglish (US)
Article number165
JournalBMC Neurology
Volume13
DOIs
StatePublished - Nov 6 2013
Externally publishedYes

Fingerprint

Ethnic Groups
Dementia
Cohort Studies
Biomarkers
Longitudinal Studies
Neuropsychological Tests
North America
Research
Meta-Analysis
Cognitive Aging
Protective Factors
Epidemiology
Research Design
Communication
Research Personnel
Databases
Cognitive Dysfunction
Population

Keywords

  • Cognitive ageing
  • Cohort studies
  • Data harmonisation
  • Dementia
  • International consortium
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

COSMIC (Cohort Studies of Memory in an International Consortium) : An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. / Sachdev, Perminder S.; Lipnicki, Darren M.; Kochan, Nicole A.; Crawford, John D.; Rockwood, Kenneth; Xiao, Shifu; Li, Juan; Li, Xia; Brayne, Carol; Matthews, Fiona E.; Stephan, Blossom C M; Lipton, Richard B.; Katz, Mindy J.; Ritchie, Karen; Carrière, Isabelle; Ancelin, Marie Laure; Seshadri, Sudha; Au, Rhoda; Beiser, Alexa S.; Lam, Linda C W; Wong, Candy H Y; Fung, Ada W T; Kim, Ki W.; Han, Ji W.; Kim, Tae H.; Petersen, Ronald C.; Roberts, Rosebud O.; Mielke, Michelle M.; Ganguli, Mary; Dodge, Hiroko H.; Hughes, Tiffany; Anstey, Kaarin J.; Cherbuin, Nicolas; Butterworth, Peter; Ng, Tze P.; Gao, Qi; Reppermund, Simone; Brodaty, Henry; Meguro, Kenichi; Schupf, Nicole; Manly, Jennifer; Stern, Yaakov; Lobo, Antonio; Lopez-Anton, Raúl; Santabárbara, Javier.

In: BMC Neurology, Vol. 13, 165, 06.11.2013.

Research output: Contribution to journalArticle

Sachdev, PS, Lipnicki, DM, Kochan, NA, Crawford, JD, Rockwood, K, Xiao, S, Li, J, Li, X, Brayne, C, Matthews, FE, Stephan, BCM, Lipton, RB, Katz, MJ, Ritchie, K, Carrière, I, Ancelin, ML, Seshadri, S, Au, R, Beiser, AS, Lam, LCW, Wong, CHY, Fung, AWT, Kim, KW, Han, JW, Kim, TH, Petersen, RC, Roberts, RO, Mielke, MM, Ganguli, M, Dodge, HH, Hughes, T, Anstey, KJ, Cherbuin, N, Butterworth, P, Ng, TP, Gao, Q, Reppermund, S, Brodaty, H, Meguro, K, Schupf, N, Manly, J, Stern, Y, Lobo, A, Lopez-Anton, R & Santabárbara, J 2013, 'COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups', BMC Neurology, vol. 13, 165. https://doi.org/10.1186/1471-2377-13-165
Sachdev, Perminder S. ; Lipnicki, Darren M. ; Kochan, Nicole A. ; Crawford, John D. ; Rockwood, Kenneth ; Xiao, Shifu ; Li, Juan ; Li, Xia ; Brayne, Carol ; Matthews, Fiona E. ; Stephan, Blossom C M ; Lipton, Richard B. ; Katz, Mindy J. ; Ritchie, Karen ; Carrière, Isabelle ; Ancelin, Marie Laure ; Seshadri, Sudha ; Au, Rhoda ; Beiser, Alexa S. ; Lam, Linda C W ; Wong, Candy H Y ; Fung, Ada W T ; Kim, Ki W. ; Han, Ji W. ; Kim, Tae H. ; Petersen, Ronald C. ; Roberts, Rosebud O. ; Mielke, Michelle M. ; Ganguli, Mary ; Dodge, Hiroko H. ; Hughes, Tiffany ; Anstey, Kaarin J. ; Cherbuin, Nicolas ; Butterworth, Peter ; Ng, Tze P. ; Gao, Qi ; Reppermund, Simone ; Brodaty, Henry ; Meguro, Kenichi ; Schupf, Nicole ; Manly, Jennifer ; Stern, Yaakov ; Lobo, Antonio ; Lopez-Anton, Raúl ; Santabárbara, Javier. / COSMIC (Cohort Studies of Memory in an International Consortium) : An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. In: BMC Neurology. 2013 ; Vol. 13.
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abstract = "Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.",
keywords = "Cognitive ageing, Cohort studies, Data harmonisation, Dementia, International consortium, Mild cognitive impairment",
author = "Sachdev, {Perminder S.} and Lipnicki, {Darren M.} and Kochan, {Nicole A.} and Crawford, {John D.} and Kenneth Rockwood and Shifu Xiao and Juan Li and Xia Li and Carol Brayne and Matthews, {Fiona E.} and Stephan, {Blossom C M} and Lipton, {Richard B.} and Katz, {Mindy J.} and Karen Ritchie and Isabelle Carri{\`e}re and Ancelin, {Marie Laure} and Sudha Seshadri and Rhoda Au and Beiser, {Alexa S.} and Lam, {Linda C W} and Wong, {Candy H Y} and Fung, {Ada W T} and Kim, {Ki W.} and Han, {Ji W.} and Kim, {Tae H.} and Petersen, {Ronald C.} and Roberts, {Rosebud O.} and Mielke, {Michelle M.} and Mary Ganguli and Dodge, {Hiroko H.} and Tiffany Hughes and Anstey, {Kaarin J.} and Nicolas Cherbuin and Peter Butterworth and Ng, {Tze P.} and Qi Gao and Simone Reppermund and Henry Brodaty and Kenichi Meguro and Nicole Schupf and Jennifer Manly and Yaakov Stern and Antonio Lobo and Ra{\'u}l Lopez-Anton and Javier Santab{\'a}rbara",
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T1 - COSMIC (Cohort Studies of Memory in an International Consortium)

T2 - An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

AU - Sachdev, Perminder S.

AU - Lipnicki, Darren M.

AU - Kochan, Nicole A.

AU - Crawford, John D.

AU - Rockwood, Kenneth

AU - Xiao, Shifu

AU - Li, Juan

AU - Li, Xia

AU - Brayne, Carol

AU - Matthews, Fiona E.

AU - Stephan, Blossom C M

AU - Lipton, Richard B.

AU - Katz, Mindy J.

AU - Ritchie, Karen

AU - Carrière, Isabelle

AU - Ancelin, Marie Laure

AU - Seshadri, Sudha

AU - Au, Rhoda

AU - Beiser, Alexa S.

AU - Lam, Linda C W

AU - Wong, Candy H Y

AU - Fung, Ada W T

AU - Kim, Ki W.

AU - Han, Ji W.

AU - Kim, Tae H.

AU - Petersen, Ronald C.

AU - Roberts, Rosebud O.

AU - Mielke, Michelle M.

AU - Ganguli, Mary

AU - Dodge, Hiroko H.

AU - Hughes, Tiffany

AU - Anstey, Kaarin J.

AU - Cherbuin, Nicolas

AU - Butterworth, Peter

AU - Ng, Tze P.

AU - Gao, Qi

AU - Reppermund, Simone

AU - Brodaty, Henry

AU - Meguro, Kenichi

AU - Schupf, Nicole

AU - Manly, Jennifer

AU - Stern, Yaakov

AU - Lobo, Antonio

AU - Lopez-Anton, Raúl

AU - Santabárbara, Javier

PY - 2013/11/6

Y1 - 2013/11/6

N2 - Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.

AB - Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.

KW - Cognitive ageing

KW - Cohort studies

KW - Data harmonisation

KW - Dementia

KW - International consortium

KW - Mild cognitive impairment

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DO - 10.1186/1471-2377-13-165

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JO - BMC Neurology

JF - BMC Neurology

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