Cortisol secretion rates were estimated by the in vivo isotope dilution technique in 16 patients with congenital virilizing adrenal hyperplasia; the data presented includes those of 2 salt losers previously published. The data were compared with those from age-matched controls. Six patients with the typical pattern of the salt-losing form had low CPR's. A seventh patient, the appearance of whose clinical manifestations was somewhat delayed and who had relatively mild salt loss, had a normal rate. Seven patients with the simple virilizing form had CPR's within the normal range. The eighth and youngest patient, aged 16 days, had a low CPR at a time when moderate transient salt loss was detected. The ninth patient was under ACTH stimulation for one week and had a CPR similar to those of the untreated patients.
|Original language||English (US)|
|Number of pages||8|
|Journal||The Journal of pediatrics|
|Issue number||5 PART 1|
|State||Published - Nov 1966|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health