Cortisol is transported by the multidrug resistance gene product P-glycoprotein

C. K. van Kalken, H. J. Broxterman, H. M. Pinedo, N. Feller, H. Dekker, J. Lankelma, G. Giaccone

Research output: Contribution to journalArticle

Abstract

The physiology of the multidrug transporter P-glycoprotein (Pgp) is still poorly understood. We now show evidence that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone. Cortisol efflux from Pgp negative cells does not have such an active component. Further we show that the steroid hormones cortisol, testosterone, and progesterone cause an immediate, dose-dependent increase of daunorubicin accumulation in Pgp overexpressing cells. These effects are particularly apparent for the more lipophilic steroids. These results demonstrate that Pgp may function as a transporter for cortisol and suggest a physiological role of the protein in steroid handling by organs such as the adrenal.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalBritish Journal of Cancer
Volume67
Issue number2
StatePublished - Feb 1993
Externally publishedYes

Fingerprint

MDR Genes
P-Glycoprotein
Hydrocortisone
Steroids
Hormones
Daunorubicin
Progesterone
Testosterone
Adenosine Triphosphate
Cell Line
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

van Kalken, C. K., Broxterman, H. J., Pinedo, H. M., Feller, N., Dekker, H., Lankelma, J., & Giaccone, G. (1993). Cortisol is transported by the multidrug resistance gene product P-glycoprotein. British Journal of Cancer, 67(2), 284-289.

Cortisol is transported by the multidrug resistance gene product P-glycoprotein. / van Kalken, C. K.; Broxterman, H. J.; Pinedo, H. M.; Feller, N.; Dekker, H.; Lankelma, J.; Giaccone, G.

In: British Journal of Cancer, Vol. 67, No. 2, 02.1993, p. 284-289.

Research output: Contribution to journalArticle

van Kalken, CK, Broxterman, HJ, Pinedo, HM, Feller, N, Dekker, H, Lankelma, J & Giaccone, G 1993, 'Cortisol is transported by the multidrug resistance gene product P-glycoprotein', British Journal of Cancer, vol. 67, no. 2, pp. 284-289.
van Kalken CK, Broxterman HJ, Pinedo HM, Feller N, Dekker H, Lankelma J et al. Cortisol is transported by the multidrug resistance gene product P-glycoprotein. British Journal of Cancer. 1993 Feb;67(2):284-289.
van Kalken, C. K. ; Broxterman, H. J. ; Pinedo, H. M. ; Feller, N. ; Dekker, H. ; Lankelma, J. ; Giaccone, G. / Cortisol is transported by the multidrug resistance gene product P-glycoprotein. In: British Journal of Cancer. 1993 ; Vol. 67, No. 2. pp. 284-289.
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