Corticotropin releasing hormone-induced potentiation of substance p-mediated contraction of guinea pig airway smooth muscle

M. A. McAlexander, Bradley J Undem

Research output: Contribution to journalArticle

Abstract

Corticotropin releasing hormone (CRH) is known to have antiinflammatory actions via the endocrine system. CRH may also serve as a local modulator of inflammation within tissues (Pharm. Rev. 43:425, 1991). In airways, CRH has been shown to acutely inhibit neurogenic tachykim'n-mediated plasma extravasation (Eur. J. Pharm. 140:63, 1987), suggesting that CRH may cause inhibition of tachykinin release from airway afferent fibers. We examined the effect of CRH on the tachykinergic contractions of the guinea pig isolated airway. Exposing the isolated guinea pig left bronchus to 1 |ig/ml CRH significantly enhanced the tachykininmediated smooth muscle contraction elicited by electrical field stimulation (8 Hz, 20V,10s) from 17.7±2.2% to 29.5±3.7% of maximum (n=8; p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

corticotropin-releasing hormone
Corticotropin-Releasing Hormone
smooth muscle
guinea pigs
Smooth Muscle
Muscle
Guinea Pigs
Tachykinins
bronchi
endocrine system
Endocrine System
muscle contraction
electric field
Bronchi
Muscle Contraction
Modulators
Electric Stimulation
Anti-Inflammatory Agents
inflammation
Tissue

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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abstract = "Corticotropin releasing hormone (CRH) is known to have antiinflammatory actions via the endocrine system. CRH may also serve as a local modulator of inflammation within tissues (Pharm. Rev. 43:425, 1991). In airways, CRH has been shown to acutely inhibit neurogenic tachykim'n-mediated plasma extravasation (Eur. J. Pharm. 140:63, 1987), suggesting that CRH may cause inhibition of tachykinin release from airway afferent fibers. We examined the effect of CRH on the tachykinergic contractions of the guinea pig isolated airway. Exposing the isolated guinea pig left bronchus to 1 |ig/ml CRH significantly enhanced the tachykininmediated smooth muscle contraction elicited by electrical field stimulation (8 Hz, 20V,10s) from 17.7±2.2{\%} to 29.5±3.7{\%} of maximum (n=8; p",
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AB - Corticotropin releasing hormone (CRH) is known to have antiinflammatory actions via the endocrine system. CRH may also serve as a local modulator of inflammation within tissues (Pharm. Rev. 43:425, 1991). In airways, CRH has been shown to acutely inhibit neurogenic tachykim'n-mediated plasma extravasation (Eur. J. Pharm. 140:63, 1987), suggesting that CRH may cause inhibition of tachykinin release from airway afferent fibers. We examined the effect of CRH on the tachykinergic contractions of the guinea pig isolated airway. Exposing the isolated guinea pig left bronchus to 1 |ig/ml CRH significantly enhanced the tachykininmediated smooth muscle contraction elicited by electrical field stimulation (8 Hz, 20V,10s) from 17.7±2.2% to 29.5±3.7% of maximum (n=8; p

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