Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway

Richard E. Powers, Errol B. DeSouza, Lary C. Walker, Donald L. Price, Wylie W. Vale, W. Scott Young

Research output: Contribution to journalArticle

Abstract

This study demonstrates that the neuropeptide, corticotropin-releasing factor (CRF), is present in neurons of the human inferior olivary complex (IOC). The medulla (including the inferior olive) and the anterior vermis of the cerebellum of 6 human controls obtained at autopsy were immunostained with an antibody directed against CRF. CRF receptors in cerebellum were localized with labeled CRF using in vitro receptor autoradiography. The great majority of neurons in all divisions of the IOC expressed CRF immunoreactivity, and CRF-immunoreactive fibers were demonstrated in the hilus of the olive and in the molecular layer of the cerebellum, where they closely resembled climbing fibers as visualized with other methods. CRF receptors were enriched in the cerebellum, with the highest density in inner portions of the molecular layer. These findings in human brain, consistent with studies in tissues from rat, cat, and monkey, demonstrate that CRF may be a peptidergic transmitter in the IOC climbing fiber system and that CRF receptors are expressed by cellular targets in the cerebellum.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalBrain Research
Volume415
Issue number2
DOIs
StatePublished - Jul 14 1987

Fingerprint

Corticotropin-Releasing Hormone
Cerebellum
Corticotropin-Releasing Hormone Receptors
Neurons
Olea
Neuropeptides
Autoradiography
Haplorhini
Autopsy
Cats
Antibodies
Brain

Keywords

  • Corticotropin-releasing factor
  • Human cerebellum
  • Inferior olive
  • Peptide

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Powers, R. E., DeSouza, E. B., Walker, L. C., Price, D. L., Vale, W. W., & Young, W. S. (1987). Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway. Brain Research, 415(2), 347-352. https://doi.org/10.1016/0006-8993(87)90218-6

Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway. / Powers, Richard E.; DeSouza, Errol B.; Walker, Lary C.; Price, Donald L.; Vale, Wylie W.; Young, W. Scott.

In: Brain Research, Vol. 415, No. 2, 14.07.1987, p. 347-352.

Research output: Contribution to journalArticle

Powers, RE, DeSouza, EB, Walker, LC, Price, DL, Vale, WW & Young, WS 1987, 'Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway', Brain Research, vol. 415, no. 2, pp. 347-352. https://doi.org/10.1016/0006-8993(87)90218-6
Powers RE, DeSouza EB, Walker LC, Price DL, Vale WW, Young WS. Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway. Brain Research. 1987 Jul 14;415(2):347-352. https://doi.org/10.1016/0006-8993(87)90218-6
Powers, Richard E. ; DeSouza, Errol B. ; Walker, Lary C. ; Price, Donald L. ; Vale, Wylie W. ; Young, W. Scott. / Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway. In: Brain Research. 1987 ; Vol. 415, No. 2. pp. 347-352.
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