Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness

Karen Sue Lindeman, C. A. Hirshman

Research output: Contribution to journalArticle

Abstract

To investigate the importance of the inflammatory response in acute peripheral airway constriction, we measured peripheral airway responses to calcium chelators and acetylcholine in anesthetized Basenji-Greyhound (BG) dogs before, during, and after chronic corticosteroid treatment. A wedged bronchoscope technique was used to measure peripheral airway resistance before and after aerosol challenge with 4% Na2EDTA or acetylcholine (10 μg/ml) in contralateral lungs. After the initial measurements, five BG dogs received long-term treatment with methylprednisolone (2 mg/kg/d, subcutaneously), and five dogs were not treated and served as controls. Four weeks of methylprednisolone treatment almost totally abolished responses to Na2EDTA, but responses to acetylcholine did not change significantly. After discontinuing corticosteroid therapy, responses to Na2EDTA returned to levels found before corticosteroid treatment; responses to acetylcholine were significantly enhanced. We conclude that chronic corticosteroid treatment reduces acute response to calcium chelators and that withdrawal of corticosteroid therapy is associated with enhanced cholinergic responsiveness.

Original languageEnglish (US)
Pages (from-to)1581-1585
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume148
Issue number6 I
StatePublished - 1993

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Cholinergic Agents
Adrenal Cortex Hormones
Acetylcholine
Methylprednisolone
Dogs
Bronchoscopes
Airway Resistance
Aerosols
Constriction
Vascular Resistance
Calcium Chelating Agents
Lung
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness. / Lindeman, Karen Sue; Hirshman, C. A.

In: American Review of Respiratory Disease, Vol. 148, No. 6 I, 1993, p. 1581-1585.

Research output: Contribution to journalArticle

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