Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response

Birte U. Forstmann; Max C. Keuken; Sara Jahfari; Pierre Louis Bazin; Jane Neumann; Andreas Schäfer; Alfred Anwander; Robert Turner

doi:10.1016/j.neuroimage.2011.12.044

Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response

Birte U. Forstmann, Max C. Keuken, Sara Jahfari, Pierre Louis Bazin, Jane Neumann, Andreas Schäfer, Alfred Anwander, Robert Turner

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.

Original language	English (US)
Pages (from-to)	370-375
Number of pages	6
Journal	NeuroImage
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroimage.2011.12.044
State	Published - Mar 2012
Externally published	Yes

Keywords

7T magnetic resonance imaging
Atlas
Diffusion weighted imaging
Stop-signal paradigm
Subthalamic nucleus

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2011.12.044

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title = "Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response",

abstract = "The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.",

keywords = "7T magnetic resonance imaging, Atlas, Diffusion weighted imaging, Stop-signal paradigm, Subthalamic nucleus",

author = "Forstmann, {Birte U.} and Keuken, {Max C.} and Sara Jahfari and Bazin, {Pierre Louis} and Jane Neumann and Andreas Sch{\"a}fer and Alfred Anwander and Robert Turner",

note = "Funding Information: This work was supported by VENI (BUF) and Mozaiek grant (SJ) from the Netherlands Organization for Scientific Research (NWO) and by the Federal Ministry of Education and Research, Germany , FKZ:01EO1001 (JN). ",

year = "2012",

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doi = "10.1016/j.neuroimage.2011.12.044",

language = "English (US)",

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AU - Forstmann, Birte U.

AU - Keuken, Max C.

AU - Jahfari, Sara

AU - Bazin, Pierre Louis

AU - Neumann, Jane

AU - Schäfer, Andreas

AU - Anwander, Alfred

AU - Turner, Robert

N1 - Funding Information: This work was supported by VENI (BUF) and Mozaiek grant (SJ) from the Netherlands Organization for Scientific Research (NWO) and by the Federal Ministry of Education and Research, Germany , FKZ:01EO1001 (JN).

PY - 2012/3

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N2 - The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.

AB - The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.

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Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response

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Keywords

ASJC Scopus subject areas

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